Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract

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Nogueira Neto, Joao [UNIFESP]
Coelho, Tarcisio Mota
Aguiar, Guilherme Carneiro
Carvalho, Laura Rosa
Portela de Araujo, Ana Giselia
Girao, Manuel Joao B. C. [UNIFESP]
Schor, Eduardo [UNIFESP]
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Objective: the aim of this study was to analyze the macroscopic and histological changes that occur in experimental endometriosis after treatment with Uncaria tomentosa.Study design: Experimental endometriosis was induced in twenty-five female Wistar rats. After three weeks, 24 animals developed grade III experimental endometriosis and were divided into two groups. Group U received U. tomentosa extract orally (32 mg/day), and group C (control group) received a 0.9% sodium chloride solution orally (1 ml/100 g of body weight/day). Both groups were treated with gavage for 14 days. At the surgical intervention and after the animal was euthanized, the implant volume was calculated with the following formula: [4 pi (length/2) x (width/2) x (height/2)/3]. the auto-transplants were removed, dyed with hematoxylin-eosin, and analyzed by light microscopy. the Mann-Whitney test was used for the independent samples, and the Wilcoxon test analyzed the related samples, with a significance level of 5%.Results: the difference between the initial average volumes of the autotransplants was not significant between the groups (p = 0.18). However, the final average volumes were significantly different between the groups (p = 0.001). There was a significant increase (p = 0.01) between the initial and final average volumes in the control group, and treatment with the U. tomentosa caused a marked reduction in the growth over time (p = 0.009). Histologically, in the experimental group (n = 10) six rats had a well-preserved epithelial layer, three had mildly preserved epithelium, and one had poorly preserved epithelium. the epithelial layer occasionally presented sporadic epithelial cells. the control group (n = 12) presented seven cases (58.3%) of well-preserved epithelial cells and five cases (41.7%) of mildly preserved epithelial cells.Conclusions: Cat's claw extract appears to be a promising alternative for treating endometriosis. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 154, n. 2, p. 205-208, 2011.