Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract

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dc.contributor.authorNogueira Neto, Joao [UNIFESP]
dc.contributor.authorCoelho, Tarcisio Mota
dc.contributor.authorAguiar, Guilherme Carneiro
dc.contributor.authorCarvalho, Laura Rosa
dc.contributor.authorPortela de Araujo, Ana Giselia
dc.contributor.authorGirao, Manuel Joao B. C. [UNIFESP]
dc.contributor.authorSchor, Eduardo [UNIFESP]
dc.contributor.institutionUniv Fed Maranhao
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:08Z
dc.date.available2016-01-24T14:06:08Z
dc.date.issued2011-02-01
dc.description.abstractObjective: the aim of this study was to analyze the macroscopic and histological changes that occur in experimental endometriosis after treatment with Uncaria tomentosa.Study design: Experimental endometriosis was induced in twenty-five female Wistar rats. After three weeks, 24 animals developed grade III experimental endometriosis and were divided into two groups. Group U received U. tomentosa extract orally (32 mg/day), and group C (control group) received a 0.9% sodium chloride solution orally (1 ml/100 g of body weight/day). Both groups were treated with gavage for 14 days. At the surgical intervention and after the animal was euthanized, the implant volume was calculated with the following formula: [4 pi (length/2) x (width/2) x (height/2)/3]. the auto-transplants were removed, dyed with hematoxylin-eosin, and analyzed by light microscopy. the Mann-Whitney test was used for the independent samples, and the Wilcoxon test analyzed the related samples, with a significance level of 5%.Results: the difference between the initial average volumes of the autotransplants was not significant between the groups (p = 0.18). However, the final average volumes were significantly different between the groups (p = 0.001). There was a significant increase (p = 0.01) between the initial and final average volumes in the control group, and treatment with the U. tomentosa caused a marked reduction in the growth over time (p = 0.009). Histologically, in the experimental group (n = 10) six rats had a well-preserved epithelial layer, three had mildly preserved epithelium, and one had poorly preserved epithelium. the epithelial layer occasionally presented sporadic epithelial cells. the control group (n = 12) presented seven cases (58.3%) of well-preserved epithelial cells and five cases (41.7%) of mildly preserved epithelial cells.Conclusions: Cat's claw extract appears to be a promising alternative for treating endometriosis. (c) 2010 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Maranhao, Univ Hosp, Expt Surg Lab, UFMA, Sao Luis, MA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, Pelv Pain & Endometriosis Unit, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, Pelv Pain & Endometriosis Unit, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent205-208
dc.identifierhttp://dx.doi.org/10.1016/j.ejogrb.2010.10.002
dc.identifier.citationEuropean Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 154, n. 2, p. 205-208, 2011.
dc.identifier.doi10.1016/j.ejogrb.2010.10.002
dc.identifier.issn0301-2115
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33414
dc.identifier.wosWOS:000288307400017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectUncaria tomentosaen
dc.subjectExperimental endometriosisen
dc.subjectDrug therapyen
dc.subjectWistar ratsen
dc.titleExperimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extracten
dc.typeinfo:eu-repo/semantics/article
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