Relação do tamoxifeno e tromboembolismo venoso profundo na intervenção cirúrgica de reconstrução de mama - revisão de literatura
Data
2022-02-10
Autores
Malagutti, Anna Carolina 
Orientadores
Crozatti, Márcia Terezinha Lonardoni
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
O câncer de mama se tornou o mais diagnosticado no mundo nas mulheres, sendo mais prevalente o que expressa receptor de hormônio. Como consequência um maior número de mulheres passou a usar o tamoxifeno como terapia adjuvante. Entretanto, alguns estudos apontam aumento de probabilidade de eventos tromboembólicos na vigência deste tratamento. A reconstrução de mama é uma cirurgia frequentemente realizada em pacientes com essa condição, e as complicações do uso de tamoxifeno nessa cirurgia podem levar a trombose, isquemia até necrose e possibilidade de perda parcial ou total do retalho. É importante estudar a relação do tamoxifeno com o tromboembolismo venoso profundo na intervenção cirúrgica de reconstrução de mama de modo a subsidiar a construção de um possível algoritmo e assim melhorar o desfecho cirúrgico. Esta relação foi estudada através de revisão da literatura. A metodologia se baseou na técnica “P.I.C.O” para formulação da estratégia de busca, utilizando a base de dados Pubmed. Foram selecionados 6 artigos, dentre os quais apenas um mostra a relação do tamoxifeno com o tromboembolismo na reconstrução de mama. Porém, os artigos apontam a necessidade de estudos mais robustos sobre o assunto, com maior amostragem, melhor capacidade de relacionar o tipo de reconstrução com o tromboembolismo e sugerem a necessidade de realizar a pausa do medicamento antes e após a cirurgia de reconstrução de mama.
Breast cancer has become the most diagnosed in the world in women, with the most prevalent being that which expresses a hormone receptor. As a result, a greater number of women began to use tamoxifen as an adjuvant therapy. However, some studies point to an increase in the probability of thromboembolic events during this treatment. Breast reconstruction is a surgery frequently performed in patients with this condition, and the complications of using tamoxifen in this surgery can lead to thrombosis, ischemia to necrosis and the possibility of partial or total loss of the flap. It is important to study the relationship between tamoxifen and deep venous thromboembolism in breast reconstruction surgery in order to support the construction of a possible algorithm and thus improve the surgical outcome. This relationship was studied through a literature review. The methodology was based on the “P.I.C.O” technique to formulate the search strategy, using the Pubmed database. Six articles were selected, among which only one showed the relationship between tamoxifen and thromboembolism in breast reconstruction. However, articles point to the need for more robust studies on the subject, with larger sampling, better ability to relate the type of reconstruction with thromboembolism, and suggest the need to pause the medication before and after breast reconstruction surgery.
Breast cancer has become the most diagnosed in the world in women, with the most prevalent being that which expresses a hormone receptor. As a result, a greater number of women began to use tamoxifen as an adjuvant therapy. However, some studies point to an increase in the probability of thromboembolic events during this treatment. Breast reconstruction is a surgery frequently performed in patients with this condition, and the complications of using tamoxifen in this surgery can lead to thrombosis, ischemia to necrosis and the possibility of partial or total loss of the flap. It is important to study the relationship between tamoxifen and deep venous thromboembolism in breast reconstruction surgery in order to support the construction of a possible algorithm and thus improve the surgical outcome. This relationship was studied through a literature review. The methodology was based on the “P.I.C.O” technique to formulate the search strategy, using the Pubmed database. Six articles were selected, among which only one showed the relationship between tamoxifen and thromboembolism in breast reconstruction. However, articles point to the need for more robust studies on the subject, with larger sampling, better ability to relate the type of reconstruction with thromboembolism, and suggest the need to pause the medication before and after breast reconstruction surgery.