POLYMORPHISM OF THE 35-KILODALTON AND 50-KILODALTON SURFACE GLYCOCONJUGATES OF TRYPANOSOMA-CRUZI METACYCLIC TRYPOMASTIGOTES
| dc.contributor.author | Mortara, Renato Arruda [UNIFESP] | |
| dc.contributor.author | Silva, Solange da [UNIFESP] | |
| dc.contributor.author | Araguth, Marcia F. [UNIFESP] | |
| dc.contributor.author | Blanco, Sandra Angela [UNIFESP] | |
| dc.contributor.author | Yoshida, Nobuko [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2018-06-15T17:38:36Z | |
| dc.date.available | 2018-06-15T17:38:36Z | |
| dc.date.issued | 1992-11-01 | |
| dc.description.abstract | In this study, we examined the immunochemical properties of the 35- and 50-kDa (35/50-kDa) surface glycoconjugates expressed on the surface of metacyclic trypomastigotes of Trypanosoma cruzi using three different monoclonal antibodies directed to this component. The 35/50-kDa surface antigen was expressed by metacyclic trypomastigotes of 11 different strains of T. cruzi and displayed a significant degree of molecular polymorphism. Results of immunoblotting and complement-mediated lysis were consistent with such diversity. Different monoclonal antibodies reacted with distinct epitopes on the 35/50-kDa antigen, which is resistant to proteases and behaves as an amphiphilic component. | en |
| dc.description.affiliation | ESCOLA PAULISTA MED SCH,DEPT MICROBIOL IMMUNOL & PARASITOL,DIV PARASITOL,RUA BOTUCATU,BR-04023 SAO PAULO,BRAZIL | |
| dc.description.affiliationUnifesp | ESCOLA PAULISTA MED SCH,DEPT MICROBIOL IMMUNOL & PARASITOL,DIV PARASITOL,RUA BOTUCATU,BR-04023 SAO PAULO,BRAZIL | |
| dc.description.source | Web of Science | |
| dc.format.extent | 4673-4678 | |
| dc.identifier | http://iai.asm.org/content/60/11/4673.abstract | |
| dc.identifier.citation | Infection And Immunity. Washington: Amer Soc Microbiology, v. 60, n. 11, p. 4673-4678, 1992. | |
| dc.identifier.issn | 0019-9567 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/43947 | |
| dc.identifier.wos | WOS:A1992JV76300031 | |
| dc.language.iso | eng | |
| dc.publisher | Amer Soc Microbiology | |
| dc.relation.ispartof | Infection And Immunity | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.title | POLYMORPHISM OF THE 35-KILODALTON AND 50-KILODALTON SURFACE GLYCOCONJUGATES OF TRYPANOSOMA-CRUZI METACYCLIC TRYPOMASTIGOTES | en |
| dc.type | info:eu-repo/semantics/article |