POLYMORPHISM OF THE 35-KILODALTON AND 50-KILODALTON SURFACE GLYCOCONJUGATES OF TRYPANOSOMA-CRUZI METACYCLIC TRYPOMASTIGOTES

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Data
1992-11-01
Autores
Mortara, Renato Arruda [UNIFESP]
Silva, Solange da [UNIFESP]
Araguth, Marcia F. [UNIFESP]
Blanco, Sandra Angela [UNIFESP]
Yoshida, Nobuko [UNIFESP]
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In this study, we examined the immunochemical properties of the 35- and 50-kDa (35/50-kDa) surface glycoconjugates expressed on the surface of metacyclic trypomastigotes of Trypanosoma cruzi using three different monoclonal antibodies directed to this component. The 35/50-kDa surface antigen was expressed by metacyclic trypomastigotes of 11 different strains of T. cruzi and displayed a significant degree of molecular polymorphism. Results of immunoblotting and complement-mediated lysis were consistent with such diversity. Different monoclonal antibodies reacted with distinct epitopes on the 35/50-kDa antigen, which is resistant to proteases and behaves as an amphiphilic component.
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Infection And Immunity. Washington: Amer Soc Microbiology, v. 60, n. 11, p. 4673-4678, 1992.
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