Porous poly (D,L-lactide-co-glycolide) acid/biosilicate((R)) composite scaffolds for bone tissue engineering

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dc.citation.issue1
dc.citation.volume105
dc.contributor.authorKido, Hueliton Wilian [UNIFESP]
dc.contributor.authorBrassolatti, Patricia
dc.contributor.authorTim, Carla Roberta [UNIFESP]
dc.contributor.authorGabbai-Armelin, Paulo Roberto [UNIFESP]
dc.contributor.authorMagri, Angela Maria Paiva [UNIFESP]
dc.contributor.authorFernandes, Kelly Rossetti [UNIFESP]
dc.contributor.authorBossini, Paulo S.
dc.contributor.authorParizotto, Nivaldo A.
dc.contributor.authorCrovace, Murilo C.
dc.contributor.authorMalavazi, Iran
dc.contributor.authorda Cunha, Anderson F.
dc.contributor.authorPlepis, Ana M. G.
dc.contributor.authorAnibal, Fernanda F.
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:46:59Z
dc.date.available2020-07-31T12:46:59Z
dc.date.issued2017
dc.description.abstractThis study evaluated the effects of the Biosilicate((R)) and poly (D,L-lactic-co-glycolic) acid composites on bone repair in a tibial bone defect model in rats by means of using histological evaluation (histopathological and morphometric analysis) and gene expression analysis. Eighty male Wistar rats (12weeks old, weighing +/- 300g) were randomly divided into two groups: Biosilicate((R)) group (BG) and Biosilicate((R))/PLGA group (BG/PLGA). Each group was euthanized at 3, 7, 14, and 21days after surgery (n=10 animals per time point). The main findings showed that the incorporation of PLGA into BG had a significant effect on the morphological structure of the material, accelerating mass loss, decreasing the pH and increasing the calcium release. Furthermore, histologic analysis revealed that the BG/PLGA showed increased material degradation, accompanied by higher bone formation compared to BG, after 21days of implantation. In addition, qRT-PCR analysis showed that BG/PLGA induced an upregulation of the osteogenic genes related to BMP4, Runx2, ALP, and OC. These results show that the present BG/PLGA composite may be used as a bone graft for inducing bone repair. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 63-71, 2017.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Biosci, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Postgrad Program Biotechnol, Dept Physiotherapy, Sao Carlos, SP, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Vitreous Mat Lab LaMaV, Dept Mat Engn, Sao Carlos, SP, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Dept Genet & Evolut, Sao Carlos, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Chem Sao Carlos, Sao Carlos, SP, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Dept Morphol & Pathol, Sao Carlos, SP, Brazil
dc.description.affiliationUnifespDepartment of Biosciences, Universidade Federal de São Paulo (UNIFESP), Santos, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent63-71
dc.identifierhttp://dx.doi.org/10.1002/jbm.b.33536
dc.identifier.citationJournal Of Biomedical Materials Research Part B-Applied Biomaterials. Hoboken, v. 105, n. 1, p. 63-71, 2017.
dc.identifier.doi10.1002/jbm.b.33536
dc.identifier.issn1552-4973
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56501
dc.identifier.wosWOS:000391804200008
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Biomedical Materials Research Part B-Applied Biomaterials
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPLGAen
dc.subjectBiosilicate((R))en
dc.subjectcompositeen
dc.subjectosteogenic genesen
dc.subjectbone repairen
dc.titlePorous poly (D,L-lactide-co-glycolide) acid/biosilicate((R)) composite scaffolds for bone tissue engineeringen
dc.typeinfo:eu-repo/semantics/article
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