Perfil neuropsicológico e de cognição social na psicose inicial: estudo exploratório de fatores de gravidade
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Data
2023-08-08
Autores
Novaes, Rafael Angulo Condoretti Barros [UNIFESP]
Orientadores
Mello, Claudia Berlim de [UNIFESP]
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
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Resumo
Introdução: A esquizofrenia é uma doença mental grave que afeta milhões de pessoas em todo o mundo. Seus sintomas podem ser divididos em três categorias principais: sintomas cognitivos, sintomas positivos e sintomas negativos. A compreensão abrangente dessas categorias é essencial para um diagnóstico precoce e uma abordagem de tratamento eficaz. Objetivo: Esta dissertação teve como objetivo analisar e comparar os sintomas cognitivos, positivos e negativos em pacientes com esquizofrenia, a fim de explorar as diferenças entre a população americana e brasileira além de compreender fatores preditivos dos sintomas para a gravidade da doença. Participantes: A amostra com dados da avaliação foi composta por 10 participantes (6 homens), com média de idade de 24,2 anos (DP = 5,27), também foram utilizados dados de banco de dados anonimizados de 50 participantes (35 homens) com média de 25,4 anos (DP= 6,70) Análise de dados: Foram utilizados testes T de uma via para verificar diferenças entre as amostras brasileiras e americanas e modelos de regressão linear para verificar preditores de cognição social e não social para sintomas positivos e negativos. Resultados: Foram encontradas diferenças estatisticamente significativas entre as populações brasileiras e americanas para os domínios de velocidade de processamento, memória operacional, aprendizagem verbal e raciocínio lógico. Dentre os domínios da cognição social, a teoria da mente e a percepção social (intrapessoal) se mostraram preditoras de sintomas positivos.
Introduction: Schizophrenia is a severe mental disorder that affects millions of people worldwide. Its symptoms can be divided into three main categories: cognitive symptoms, positive symptoms, and negative symptoms. A comprehensive understanding of these categories is essential for early diagnosis and effective treatment approaches. Objective: This dissertation aims to analyze and compare cognitive, positive, and negative symptoms in patients with schizophrenia, exploring the differences between the American and Brazilian populations, as well as understanding predictive factors of symptom severity in the disease. Participants: The sample with evaluation data was made up of 10 participants (6 men), with a mean age of 24.2 years (SD = 5.27), and anonymized database data from 50 participants (35 men) with a mean age of 25.4 years (SD = 6.70) was also used. Data Analysis: One-way T-tests were used to verify differences between the Brazilian and American samples, and linear regression models were used to identify predictors of social and non-social cognition for positive and negative symptoms. Results: Statistically significant differences were found between the Brazilian and American populations for domains of processing speed, working memory, verbal learning, and logical reasoning. Among the domains of social cognition, theory of mind and social perception (intrapersonal) were found to be predictors of positive symptoms.
Introduction: Schizophrenia is a severe mental disorder that affects millions of people worldwide. Its symptoms can be divided into three main categories: cognitive symptoms, positive symptoms, and negative symptoms. A comprehensive understanding of these categories is essential for early diagnosis and effective treatment approaches. Objective: This dissertation aims to analyze and compare cognitive, positive, and negative symptoms in patients with schizophrenia, exploring the differences between the American and Brazilian populations, as well as understanding predictive factors of symptom severity in the disease. Participants: The sample with evaluation data was made up of 10 participants (6 men), with a mean age of 24.2 years (SD = 5.27), and anonymized database data from 50 participants (35 men) with a mean age of 25.4 years (SD = 6.70) was also used. Data Analysis: One-way T-tests were used to verify differences between the Brazilian and American samples, and linear regression models were used to identify predictors of social and non-social cognition for positive and negative symptoms. Results: Statistically significant differences were found between the Brazilian and American populations for domains of processing speed, working memory, verbal learning, and logical reasoning. Among the domains of social cognition, theory of mind and social perception (intrapersonal) were found to be predictors of positive symptoms.
Descrição
Citação
NOVAES, Rafael Angulo Condoretti Barros. Perfil neuropsicológico e de cognição social na psicose inicial: estudo exploratório de fatores de gravidade. 2023. 69 f. Dissertação (Mestrado em Psicobiologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP). São Paulo, 2023.