Association of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian cancer

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dc.contributor.authorCorrêa, Silvana Aparecida Alves [UNIFESP]
dc.contributor.authorRibeiro de Noronha, Samuel Marcos [UNIFESP]
dc.contributor.authorAlecrim, Cheryl [UNIFESP]
dc.contributor.authorMesquita, Adriana de Carvalho [UNIFESP]
dc.contributor.authorSilva Brito, Gabriela Soares da [UNIFESP]
dc.contributor.authorJunqueira, Michele Gilvana [UNIFESP]
dc.contributor.authorLeite, Daniela Batista [UNIFESP]
dc.contributor.authorCarvalho, Cristina Valletta de [UNIFESP]
dc.contributor.authorCotrim Guerreiro da Silva, Ismael Dale [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:59Z
dc.date.available2016-01-24T14:27:59Z
dc.date.issued2012-11-01
dc.description.abstractAssociations have been found between the angiotensin-converting enzyme insertion deletion (I/D) polymorphism (ACE I/D) and endometrial and epithelial ovarian cancer (EC and EOC, respectively). in this study, the following frequencies for each of three ACE polymorphisms, DD, ID, and II, respectively, were observed: in the EC group, 55, 24, and 21% versus the control group 39, 40, and 21% (p = 0.033*); in the EOC group 49, 36, and 15% versus the control group 49, 33, and 18% (p = 0.82). According to these allelic distributions, DD carriers are 2.0 times more likely than individuals carrying the ID or II genotypes to develop EC; therefore, the DD genotype seems to be protective against EC. in contrast, no association was observed between ACE (I/D) polymorphism with EOC. the ACE (I/D) polymorphism might play a role in the pathogenesis of EC and it should be considered when identifying genetic markers for EC.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2005/54160-2
dc.format.extent889-891
dc.identifierhttp://dx.doi.org/10.3109/09513590.2012.683060
dc.identifier.citationGynecological Endocrinology. New York: Informa Healthcare, v. 28, n. 11, p. 889-891, 2012.
dc.identifier.doi10.3109/09513590.2012.683060
dc.identifier.issn0951-3590
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35494
dc.identifier.wosWOS:000309938700014
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectAngiotensin converting enzymeen
dc.subjectendometrial canceren
dc.subjectovarian canceren
dc.titleAssociation of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian canceren
dc.typeinfo:eu-repo/semantics/article
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