Association of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian cancer
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2012-11-01
Autores
Corrêa, Silvana Aparecida Alves 
Ribeiro de Noronha, Samuel Marcos
Alecrim, Cheryl
Mesquita, Adriana de Carvalho
Silva Brito, Gabriela Soares da
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Associations have been found between the angiotensin-converting enzyme insertion deletion (I/D) polymorphism (ACE I/D) and endometrial and epithelial ovarian cancer (EC and EOC, respectively). in this study, the following frequencies for each of three ACE polymorphisms, DD, ID, and II, respectively, were observed: in the EC group, 55, 24, and 21% versus the control group 39, 40, and 21% (p = 0.033*); in the EOC group 49, 36, and 15% versus the control group 49, 33, and 18% (p = 0.82). According to these allelic distributions, DD carriers are 2.0 times more likely than individuals carrying the ID or II genotypes to develop EC; therefore, the DD genotype seems to be protective against EC. in contrast, no association was observed between ACE (I/D) polymorphism with EOC. the ACE (I/D) polymorphism might play a role in the pathogenesis of EC and it should be considered when identifying genetic markers for EC.
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Gynecological Endocrinology. New York: Informa Healthcare, v. 28, n. 11, p. 889-891, 2012.