Short and long term impact of adenotonsillectomy on the immune system

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dc.contributor.authorSantos, Fabio Pires [UNIFESP]
dc.contributor.authorWeber, Raimar
dc.contributor.authorFortes, Bibiana Callegaro
dc.contributor.authorNagata Pignatari, Shirley Shizue [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionProf Edmundo Vasconcelos Hosp
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionProf Edmund Vasconcelos Hosp
dc.contributor.institutionBrazilian ENT HNS Assoc
dc.date.accessioned2016-01-24T14:30:58Z
dc.date.available2016-01-24T14:30:58Z
dc.date.issued2013-01-01
dc.description.abstractPalatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. the possible effects of adenotonsillectomy upon the immune system remain controversial.Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children.Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 month's after surgery (short term), and 12-14 months after surgery (long term).Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group.Conclusion: 'This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.en
dc.description.affiliationUNIFESP EPM, Otol & Ear Surg Serv, São Paulo, Brazil
dc.description.affiliationProf Edmundo Vasconcelos Hosp, ENT Clin, Brazilian ENT HNS Assoc ENT, Moema, SP, Brazil
dc.description.affiliationFMUSP, São Paulo, Brazil
dc.description.affiliationProf Edmund Vasconcelos Hosp, ENT Clin, Moema, SP, Brazil
dc.description.affiliationUNIFESP EPM, São Paulo, Brazil
dc.description.affiliationBrazilian ENT HNS Assoc, São Paulo, Brazil
dc.description.affiliationProf Edmundo Vasconcelos Hosp, ENT Clin, UNIFESP EPM ENT, Dept ENT, Moema, SP, Brazil
dc.description.affiliationProf Edmundo Vasconcelos Hosp, ENT Clin, Moema, SP, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Otol & Ear Surg Serv, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUnifespProf Edmundo Vasconcelos Hosp, ENT Clin, UNIFESP EPM ENT, Dept ENT, Moema, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent28-34
dc.identifierhttp://dx.doi.org/10.5935/1808-8694.20130006
dc.identifier.citationBrazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 1, p. 28-34, 2013.
dc.identifier.doi10.5935/1808-8694.20130006
dc.identifier.fileS1808-86942013000100006.pdf
dc.identifier.issn1808-8694
dc.identifier.scieloS1808-86942013000100006
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35760
dc.identifier.wosWOS:000315660800006
dc.language.isoeng
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectadenoidectomyen
dc.subjectchilden
dc.subjectimmune systemen
dc.titleShort and long term impact of adenotonsillectomy on the immune systemen
dc.title.alternativeRepercussão da adenotonsilectomia sobre o sistema imune a curto e longo prazopt
dc.typeinfo:eu-repo/semantics/article
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