Short and long term impact of adenotonsillectomy on the immune system
Data
2013-01-01
Autores
Santos, Fabio Pires 
Nagata Pignatari, Shirley Shizue
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Palatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. the possible effects of adenotonsillectomy upon the immune system remain controversial.Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children.Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 month's after surgery (short term), and 12-14 months after surgery (long term).Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group.Conclusion: 'This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.
Descrição
Citação
Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 1, p. 28-34, 2013.