Short and long term impact of adenotonsillectomy on the immune system

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2013-01-01
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Palatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. the possible effects of adenotonsillectomy upon the immune system remain controversial.Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children.Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 month's after surgery (short term), and 12-14 months after surgery (long term).Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group.Conclusion: 'This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.
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Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 1, p. 28-34, 2013.
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