Formation of silk fibroin hydrogel and evaluation of its drug release profile

Página do item simplificado
dc.contributor.authorMoraes, Mariana Agostini de [UNIFESP]
dc.contributor.authorAlbrecht Mahl, Cynthia Regina
dc.contributor.authorSilva, Mariana Ferreira
dc.contributor.authorBeppu, Marisa Masumi
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:24Z
dc.date.available2016-01-24T14:40:24Z
dc.date.issued2015-04-15
dc.description.abstractSilk hydrogels are interesting materials to be used as matrix in controlled drug delivery devices. However, methods to accelerate fibroin gelation and allow the drug incorporation during the hydrogel preparation are needed in literature. in this article we report the preparation of silk fibroin hydrogels with addition of several contents of ethanol, used to accelerate fibroin gelation kinetics, and we also evaluate the potential of these hydrogels to be used as matrices for drug delivery. Chemical and conformational properties did not change despite the amount of ethanol incorporated in the hydrogel. Hydrogels containing diclofenac sodium dissolved in ethanol showed a faster initial release of the drug than hydrogels with the drug dissolved in water but equilibrium was reached later. This indicates a more sustained drug delivery from hydrogels in which the model drug was dissolved in ethanol. Fibroin hydrogels confirm their promising use as biopolymeric matrices for controlled drug release. (C) 2015 Wiley Periodicals, Inc.en
dc.description.affiliationUniv Estadual Campinas, Sch Chem Engn, Dept Mat & Bioproc Engn, UNICAMP, BR-13083852 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Exact & Earth Sci, Diadema, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Exact & Earth Sci, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1002/APP.41802
dc.identifier.citationJournal of Applied Polymer Science. Hoboken: Wiley-Blackwell, v. 132, n. 15, 6 p., 2015.
dc.identifier.doi10.1002/APP.41802
dc.identifier.issn0021-8995
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39006
dc.identifier.wosWOS:000348313000014
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Applied Polymer Science
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectbiopolymers and renewable polymersen
dc.subjectdrug delivery systemsen
dc.subjectgelsen
dc.titleFormation of silk fibroin hydrogel and evaluation of its drug release profileen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral