Formation of silk fibroin hydrogel and evaluation of its drug release profile
Data
2015-04-15
Autores
Moraes, Mariana Agostini de 
Tipo
Artigo
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Resumo
Silk hydrogels are interesting materials to be used as matrix in controlled drug delivery devices. However, methods to accelerate fibroin gelation and allow the drug incorporation during the hydrogel preparation are needed in literature. in this article we report the preparation of silk fibroin hydrogels with addition of several contents of ethanol, used to accelerate fibroin gelation kinetics, and we also evaluate the potential of these hydrogels to be used as matrices for drug delivery. Chemical and conformational properties did not change despite the amount of ethanol incorporated in the hydrogel. Hydrogels containing diclofenac sodium dissolved in ethanol showed a faster initial release of the drug than hydrogels with the drug dissolved in water but equilibrium was reached later. This indicates a more sustained drug delivery from hydrogels in which the model drug was dissolved in ethanol. Fibroin hydrogels confirm their promising use as biopolymeric matrices for controlled drug release. (C) 2015 Wiley Periodicals, Inc.
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Citação
Journal of Applied Polymer Science. Hoboken: Wiley-Blackwell, v. 132, n. 15, 6 p., 2015.