Estudo in sílico da toxicologia do Bisfenol A
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Data
2023-10-18
Autores
Oliveira, Caroline Costa de [UNIFESP]
Orientadores
Hernández, Raul Bonne [UNIFESP]
Tipo
Trabalho de conclusão de curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Este trabalho aborda a exposição crônica ao Bisfenol A (BFA), que tem sido associada
a diversos efeitos toxicológicos. No entanto, a falta de elucidação para os mecanismos
moleculares e metabólicos associados à toxicidade resultante dessa exposição continua sendo
uma lacuna significativa na comunidade científica. Portanto, a problemática deste estudo reside
na necessidade de compreender como o BFA afeta as vias metabólicas subjacentes associadas
e se essas mudanças são evolutivamente conservadas. A hipótese proposta é que a exposição
prolongada ao BFA leva a alterações significativas nas vias metabólicas, afetando processos
metabólicos críticos e possivelmente sendo uma resposta adaptativa à toxicidade.
Nossos resultados para a investigação in sílico, da interação proteínaproteína,
conduzida
com o auxílio das ferramentas STRING, WikiPathways, Reactome e Gene Ontology, revelaram
que o BFA afeta negativamente a via do Proteassoma (dre03050), via da Meiose oocitária
(dr04114), via do Ribossomo (dre03010), via da Proteólise Mediada pela Ubiquitina (dr04120)
e a via da Mitofagia Animal (dr04137). Essas alterações parecem ser conservadas
filogeneticamente, desde E.coli até humanos, onde são associadas ao desenvolvimento de
algumas doenças.
This summary addresses chronic exposure to Bisphenol A (BPA), which has been associated with various toxicological effects. However, the lack of elucidation of the molecular and metabolic mechanisms associated with the toxicity resulting from this exposure remains a significant gap in the scientific community. Therefore, the problem of this study lies in the need to understand how BPA affects the metabolic pathways and whether these changes are evolutionarily conserved. The proposed hypothesis is that prolonged exposure to BPA leads to significant alterations in metabolic pathways, affecting critical metabolic processes and possibly constituting an adaptive response to toxicity. Our results from in silico investigation of protein-protein interaction, conducted through STRING, WikiPathways, Reactome, and Gene Ontology tools, revealed that BPA negatively affects the Proteasome (dre03050), Oocyte Meiosis (dr04114), Ribosome (dre03010), Ubiquitin-Mediated Proteolysis (dr04120), and Animal Mitophagy pathways (dr04137). These changes appear to be phylogenetically conserved, from E.coli to humans, where they are associated with the development of some diseases.
This summary addresses chronic exposure to Bisphenol A (BPA), which has been associated with various toxicological effects. However, the lack of elucidation of the molecular and metabolic mechanisms associated with the toxicity resulting from this exposure remains a significant gap in the scientific community. Therefore, the problem of this study lies in the need to understand how BPA affects the metabolic pathways and whether these changes are evolutionarily conserved. The proposed hypothesis is that prolonged exposure to BPA leads to significant alterations in metabolic pathways, affecting critical metabolic processes and possibly constituting an adaptive response to toxicity. Our results from in silico investigation of protein-protein interaction, conducted through STRING, WikiPathways, Reactome, and Gene Ontology tools, revealed that BPA negatively affects the Proteasome (dre03050), Oocyte Meiosis (dr04114), Ribosome (dre03010), Ubiquitin-Mediated Proteolysis (dr04120), and Animal Mitophagy pathways (dr04137). These changes appear to be phylogenetically conserved, from E.coli to humans, where they are associated with the development of some diseases.