Profile of Latex Sensitization and Allergies in Children and Adolescents With Myelomeningocele in Sao Paulo, Brazil

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dc.contributor.authorBueno de Sa, A. [UNIFESP]
dc.contributor.authorFaria Camilo Araujo, R. [UNIFESP]
dc.contributor.authorCavalheiro, S. [UNIFESP]
dc.contributor.authorCarvalho Mallozi, M. [UNIFESP]
dc.contributor.authorSole, D. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T18:02:41Z
dc.date.available2018-06-15T18:02:41Z
dc.date.issued2013-01-01
dc.description.abstractBackground: Latex allergy is an important cause of occupational allergy. In many countries the prevalence of latex allergy is still high and the profile of latex sensitization is unknown.Objectives: To evaluate the frequency of sensitization and allergy to latex in children and adolescents with myelomeningocele and to identify associated risk factors.Methods: The study included 55 children and adolescents with myelomeningocele followed at a specialized center. In addition to a standard questionnaire and skin prick tests (SPTs) to aeroallergens and total latex, the patients underwent determination of total and specific serum IgE to latex and recombinant allergens.Results: We observed a prevalence of 25% for latex sensitization and of 20% for latex allergy. Twenty-four patients (43.6%) were atopic and the average age for the first reaction to latex was 44.5 months. Cutaneous reactions were the most frequently reported reactions (72.7%). Specific immunoglobulin (Ig) E to rHey b 1, rHev b 3, rHev b 5, rHey b 6.1, and rHev b 6.2 was detected in over 50% of patients allergic,to latex. Multivariate analysis showed current asthma, atopy, and having undergone 4 or more operations to be risk factors for latex sensitization.Conclusions: Our study documented a high prevalence of sensitization and allergy to latex in patients with myelomeningocele. Specific IgE to rHey b 1, rHey b 3, rHev b 5, rHey b 6.1, and rHey b 6.2 was detected in over 50% of children and adolescents with myelomeningocele who are allergic to latex. A history of current asthma, atopy, and having undergone 4 or more operations were independent risk factors for latex allergy.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Div Allergy & Clin Immunol & Rheumatol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol, Div Neurosurg, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Div Allergy & Clin Immunol & Rheumatol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol, Div Neurosurg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent43-49
dc.identifierhttp://www.jiaci.org/summary/vol23-issue1-num949
dc.identifier.citationJournal Of Investigational Allergology And Clinical Immunology. Barcelona: Esmon Publicidad S A, v. 23, n. 1, p. 43-49, 2013.
dc.identifier.issn1018-9068
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44459
dc.identifier.wosWOS:000316536500007
dc.language.isoeng
dc.publisherEsmon Publicidad S A
dc.relation.ispartofJournal Of Investigational Allergology And Clinical Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAllergyen
dc.subjectLatexen
dc.subjectMyelomeningoceleen
dc.subjectRecombinant allergensen
dc.subjectBrazilen
dc.titleProfile of Latex Sensitization and Allergies in Children and Adolescents With Myelomeningocele in Sao Paulo, Brazilen
dc.typeinfo:eu-repo/semantics/article
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