Profile of Latex Sensitization and Allergies in Children and Adolescents With Myelomeningocele in Sao Paulo, Brazil
Data
2013-01-01
Autores
Bueno de Sa, A. 
Faria Camilo Araujo, R.
Cavalheiro, S.
Carvalho Mallozi, M.
Sole, D.
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Background: Latex allergy is an important cause of occupational allergy. In many countries the prevalence of latex allergy is still high and the profile of latex sensitization is unknown.Objectives: To evaluate the frequency of sensitization and allergy to latex in children and adolescents with myelomeningocele and to identify associated risk factors.Methods: The study included 55 children and adolescents with myelomeningocele followed at a specialized center. In addition to a standard questionnaire and skin prick tests (SPTs) to aeroallergens and total latex, the patients underwent determination of total and specific serum IgE to latex and recombinant allergens.Results: We observed a prevalence of 25% for latex sensitization and of 20% for latex allergy. Twenty-four patients (43.6%) were atopic and the average age for the first reaction to latex was 44.5 months. Cutaneous reactions were the most frequently reported reactions (72.7%). Specific immunoglobulin (Ig) E to rHey b 1, rHev b 3, rHev b 5, rHey b 6.1, and rHev b 6.2 was detected in over 50% of patients allergic,to latex. Multivariate analysis showed current asthma, atopy, and having undergone 4 or more operations to be risk factors for latex sensitization.Conclusions: Our study documented a high prevalence of sensitization and allergy to latex in patients with myelomeningocele. Specific IgE to rHey b 1, rHey b 3, rHev b 5, rHey b 6.1, and rHey b 6.2 was detected in over 50% of children and adolescents with myelomeningocele who are allergic to latex. A history of current asthma, atopy, and having undergone 4 or more operations were independent risk factors for latex allergy.
Descrição
Citação
Journal Of Investigational Allergology And Clinical Immunology. Barcelona: Esmon Publicidad S A, v. 23, n. 1, p. 43-49, 2013.