Estudo da relação entre óxido nítrico com o teste de velocidade de marcha e fragilidade em idosos longevos independentes
Data
2019-01-31
Autores
Di Tommaso, Ana Beatriz Galhardi 
Orientadores
Cendoroglo, Maysa Seabra
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Introdução: Os potenciais mecanismos que levam à longevidade têm sido cada vez mais estudados. O óxido nítrico desencadeia múltiplas vias de transdução de sinal e contribui para o controle de numerosas funções celulares e por isso pode ter efeitos sobre o envelhecimento frágil e a expectativa de vida. Objetivos: Avaliar a relação do NO com a velocidade de marcha e marcadores de fragilidade em idosos longevos independentes. Métodos: Foram incluídos 91 idosos da comunidade com idade média de 87,9 anos, independentes e com cognição preservada. Os critérios de Fragilidade utilizados foram os propostos por Fried e col, a avaliação da atividade física foi feita de acordo com o questionário de Minesotta, a medida de força de preensão palmar aferida com o dinamômetro de Jamar® e a avaliação da velocidade de marcha foi realizada considerando-se uma distância de 4 metros percorridos. O óxido nítrico foi dosado pelo método de quimioluminescência. Resultados: A distribuição do perfil de fragilidade encontrada foi de 52,7% de idosos pré-frágeis, 25,3% frágeis e 22% robustos. A perda de peso no último ano foi relatada em 13,2% dos idosos e 25,3% referiram exaustão. Apesar de 54,9% dos idosos serem considerados ativos pelo questionário de Minesota, 54,4% apresentavam VM abaixo de 0,8m/s. Observamos níveis maiores de NO em indivíduos robustos (média de 234,6 uM) quando comparados com pré-frágeis (215,6 uM) e frágeis (206,4uM) bem como uma significante correlação entre os valores de índice de massa corpórea (IMC) e de NO: cada aumento de 1 kg/m2 no IMC, verificou-se um aumento de 8,39uM dos níveis de NO controlado pela presença das demais variáveis preditoras. Conclusão: Os níveis aumentados de NO podem representar um marcador de melhores desfechos de saúde e longevidade em idosos longevos independentes.
Introduction: The potential mechanisms that lead to longevity have been increasingly studied. Nitric oxide triggers multiple pathways of signal transduction and contributes to the control of numerous cellular functions and thus can have effects on frailty aging and life expectancy. Objectives: Evaluate the relationship between serum levels of nitric oxide with gait speed and markers of frailty in the independent oldest old. Methods: Ninety-one elderly individuals from the community with a mean age of 87.9 years, with functional independence and with preserved cognition were included. The frailty criteria used were those proposed by Fried et al, the physical activity evaluation was done according to the Minesotta questionnaire, the palmar grip strength measured with the Jamar® dynamometer and the gait speed evaluation performed considering a distance of 4 meters covered. Nitric oxide was measured by the chemiluminescence method. Results: The distribution of the fragility profile found was 52.7% of pre-frail elderly, 25.3% frail and 22% robust. Weight loss in the last year was reported in 13.2% of the elderly, and 25.3% reported exhaustion. The majority presented an excellent physical performance (54.9% active vs. 45.1% inactive), although 54.5% had a gait speed below 0.8m/s. There was a tendency to higher NO levels in robust individuals (mean 234.6 μM) as compared to pre-frail (215.6 μM) and frail (206.4 μM) as well as a significant correlation between body mass (BMI) and NO: each increase of 1 kg/m2 in BMI, there was an increase of 8.39 μM in NO levels controlled by the presence of other predictors. Conclusion: Increased levels of NO may represent a marker of better health outcomes and longevity in elderly with functional independence.
Introduction: The potential mechanisms that lead to longevity have been increasingly studied. Nitric oxide triggers multiple pathways of signal transduction and contributes to the control of numerous cellular functions and thus can have effects on frailty aging and life expectancy. Objectives: Evaluate the relationship between serum levels of nitric oxide with gait speed and markers of frailty in the independent oldest old. Methods: Ninety-one elderly individuals from the community with a mean age of 87.9 years, with functional independence and with preserved cognition were included. The frailty criteria used were those proposed by Fried et al, the physical activity evaluation was done according to the Minesotta questionnaire, the palmar grip strength measured with the Jamar® dynamometer and the gait speed evaluation performed considering a distance of 4 meters covered. Nitric oxide was measured by the chemiluminescence method. Results: The distribution of the fragility profile found was 52.7% of pre-frail elderly, 25.3% frail and 22% robust. Weight loss in the last year was reported in 13.2% of the elderly, and 25.3% reported exhaustion. The majority presented an excellent physical performance (54.9% active vs. 45.1% inactive), although 54.5% had a gait speed below 0.8m/s. There was a tendency to higher NO levels in robust individuals (mean 234.6 μM) as compared to pre-frail (215.6 μM) and frail (206.4 μM) as well as a significant correlation between body mass (BMI) and NO: each increase of 1 kg/m2 in BMI, there was an increase of 8.39 μM in NO levels controlled by the presence of other predictors. Conclusion: Increased levels of NO may represent a marker of better health outcomes and longevity in elderly with functional independence.