Amlodipine 2.5 mg once daily in older hypertensives: a Brazilian multi-centre study
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2004-04-01
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Objectives the use of low-dose amlodipine has not yet been well established in the elderly. This study therefore aimed to evaluate the efficacy and tolerability of low-dose amlodipine in elderly patients with Joint National Committee VI stage I or II hypertension.Patients and methods Sixty-five hypertensive individuals (aged 66.3 +/- 5.3 years) received amlodipine 2.5 mg per day for 12 weeks before and after two periods of 4 weeks of placebo. At weeks 0, 12 and 16, patients were submitted to office, 24 h ambulatory blood pressure monitoring and home blood pressure measurement.Results Office systolic and diastolic blood pressure showed decreases at weeks 8 (153 +/- 17,90 +/- 9 mmHg) and 12 (152 +/- 16, 90 +/- 9 mmHg) compared with weeks 0 (164 +/- 16, 99 +/- 6 mmHg) and 16 (162 +/- 19, 95 +/- 9 mmHg). During ambulatory monitoring, a decrease was observed in the average 24 h systolic and diastolic pressure at week 12 (143 +/- 13, 86 +/- 7 mmHg) compared with weeks 0 (155 +/- 15, 93 +/- 6 mmHg) and 16 (152 +/- 16, 92 +/- 8 mmHg). A daytime and night-time reduction in systolic and diastolic pressure was observed on home blood pressure monitoring at week 12 (146 +/- 16/88 +/- 8, 144 +/- 16/93 +/- 8 mmHg) compared with weeks 0 (1159 +/- 17/94 +/- 8,161 +/- 19/93 +/- 8 mmHg) and 16 (153 +/-16/93 +/- 8, 154 +/- 17/92 +/- 8 mmHg). Adverse reactions were infrequent.Conclusions Amlodipine at a dose of 2.5 mg per day showed efficacy and good tolerability in elderly hypertensives. (C) 2004 Lippincott Williams Wilkins.
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Blood Pressure Monitoring. Philadelphia: Lippincott Williams & Wilkins, v. 9, n. 2, p. 83-89, 2004.