Amlodipine 2.5 mg once daily in older hypertensives: a Brazilian multi-centre study

Amlodipine 2.5 mg once daily in older hypertensives: a Brazilian multi-centre study

Autor Mion, D. Google Scholar
Ortega, K. C. Google Scholar
Gomes, MAM Google Scholar
Kohlmann, O. Google Scholar
Oigman, W. Google Scholar
Nobre, F. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ State Rio de Janeiro
Resumo Objectives the use of low-dose amlodipine has not yet been well established in the elderly. This study therefore aimed to evaluate the efficacy and tolerability of low-dose amlodipine in elderly patients with Joint National Committee VI stage I or II hypertension.Patients and methods Sixty-five hypertensive individuals (aged 66.3 +/- 5.3 years) received amlodipine 2.5 mg per day for 12 weeks before and after two periods of 4 weeks of placebo. At weeks 0, 12 and 16, patients were submitted to office, 24 h ambulatory blood pressure monitoring and home blood pressure measurement.Results Office systolic and diastolic blood pressure showed decreases at weeks 8 (153 +/- 17,90 +/- 9 mmHg) and 12 (152 +/- 16, 90 +/- 9 mmHg) compared with weeks 0 (164 +/- 16, 99 +/- 6 mmHg) and 16 (162 +/- 19, 95 +/- 9 mmHg). During ambulatory monitoring, a decrease was observed in the average 24 h systolic and diastolic pressure at week 12 (143 +/- 13, 86 +/- 7 mmHg) compared with weeks 0 (155 +/- 15, 93 +/- 6 mmHg) and 16 (152 +/- 16, 92 +/- 8 mmHg). A daytime and night-time reduction in systolic and diastolic pressure was observed on home blood pressure monitoring at week 12 (146 +/- 16/88 +/- 8, 144 +/- 16/93 +/- 8 mmHg) compared with weeks 0 (1159 +/- 17/94 +/- 8,161 +/- 19/93 +/- 8 mmHg) and 16 (153 +/-16/93 +/- 8, 154 +/- 17/92 +/- 8 mmHg). Adverse reactions were infrequent.Conclusions Amlodipine at a dose of 2.5 mg per day showed efficacy and good tolerability in elderly hypertensives. (C) 2004 Lippincott Williams Wilkins.
Palavra-chave hypertension
elderly people
amlodipine
ambulatory blood pressure monitoring
home blood pressure measurement
Idioma Inglês
Data de publicação 2004-04-01
Publicado em Blood Pressure Monitoring. Philadelphia: Lippincott Williams & Wilkins, v. 9, n. 2, p. 83-89, 2004.
ISSN 1359-5237 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 83-89
Fonte http://dx.doi.org/10.1097/01.mbp.0000126524.21982.9f
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000221281600005
Endereço permanente http://repositorio.unifesp.br/handle/11600/27704

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta