Avaliação da Memória Prospectiva antes e após o uso do extrato concentrado de soja, em mulheres na pós-menopausa com queixa de alteração de memória
Data
2013
Autores
Laprano Vieira, Lucia Helena 
Orientadores
Silva, Ivaldo
Tipo
Tese de doutorado
Título da Revista
ISSN da Revista
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Resumo
O objetivo deste estudo foi analisar os efeitos do extrato concentrado de soja na memoria prospectiva (MP), apos a menopausa, por meio de avaliacao neuropsicologica. Correlacionou-se o desempenho no teste de MP, com testes de funcoes cognitivas. (funcoes atencionais, executivas, memoria, viso-motora, abstracao e linguagem), escalas de autopercepcao e depressao. Realizou-se estudo randomizado, duplo-cego, prospectivo, com 84 pacientes na posmenopausa, atendidas no Setor de Transicao Menopausal e Pos-Menopausa da Disciplina de Endocrinologia Ginecologia, do Departamento de Ginecologia da Universidade Federal de São Paulo u Escola Paulista de Medicina (UNIFESPEPM). As pacientes foram divididas, conforme programa de randomizacao, em dois grupos Grupo I - receberam 150mg de extrato concentrado de soja sob a forma de uma capsula com 60mg de isoflavonas totais, por via oral/dia; Grupo II - receberam uma capsula contendo substancia inativa (placebo), durante seis meses. Os nossos resultados demonstraram que as mulheres em uso de extrato de isoflavonas tiveram melhora clinicamente (autopercepcao) no desempenho da memoria prospectiva (MP), entretanto nao foi possivel estabelecer correlacao destes resultados com o desempenho cognitivo. O extrato concentrado de soja teve um efeito favoravel sobre a funcao cognitiva, dentre todas as funcoes, somente na memoria verbal e tarefas da funcao executiva de planejamento e flexibilidade mental, nas demais nao teve melhora. Concluimos que o extrato concentrado tem acao somente em algumas funcoes cognitivas
The purpose of this study was to analyze the effects of the soybean concentrate in the prospective memory (PM) after menopause period using neuropsychological evaluation. The performance in the PM tests was correlated to cognitive functions (attention, executive, memory, visual-motor, abstraction, and language functions), self-perception and depression scales. This study was a randomized, double-blind, prospective with 84 postmenopaused women assisted in the outpatient clinic of Menopausal Transition and Postmenopause Sector of the Endocrinology and Gynecology - School of Medicine of the Federal University of São Paulo (UNIFESP-EPM). The women were distributed into two groups: in Group I, receiving 150 mg of the soybean concentrate in the form of a capsule with 60 mg of total isoflavones orally/day; the subjects in Group II receiving a capsule containing an inactive substance (placebo) during six-month. The results obtained demonstrated that women using the isoflavone extract experienced clinical improvement (self-perception) in the performance of the PM. No association between the medication use and general cognitive performance was observed. However, on soy group, increased verbal memory, executive planning function and mental flexibility was observed. We concluded that the soybean concentrate acts specifically in some cognitive functions.
The purpose of this study was to analyze the effects of the soybean concentrate in the prospective memory (PM) after menopause period using neuropsychological evaluation. The performance in the PM tests was correlated to cognitive functions (attention, executive, memory, visual-motor, abstraction, and language functions), self-perception and depression scales. This study was a randomized, double-blind, prospective with 84 postmenopaused women assisted in the outpatient clinic of Menopausal Transition and Postmenopause Sector of the Endocrinology and Gynecology - School of Medicine of the Federal University of São Paulo (UNIFESP-EPM). The women were distributed into two groups: in Group I, receiving 150 mg of the soybean concentrate in the form of a capsule with 60 mg of total isoflavones orally/day; the subjects in Group II receiving a capsule containing an inactive substance (placebo) during six-month. The results obtained demonstrated that women using the isoflavone extract experienced clinical improvement (self-perception) in the performance of the PM. No association between the medication use and general cognitive performance was observed. However, on soy group, increased verbal memory, executive planning function and mental flexibility was observed. We concluded that the soybean concentrate acts specifically in some cognitive functions.
Descrição
Citação
VIEIRA, Lucia Helena Laprano. Avaliação da Memória Prospectiva antes e após o uso do extrato concentrado de soja, em mulheres na pós-menopausa com queixa de alteração de memória.2013. 112f. Tese (Doutorado em Ginecologia) – Escola Paulista de Medicina, Universidade Federal de São Paulo. São Paulo, 2013