Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood

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dc.contributor.authorYamada, Karen Yukie [UNIFESP]
dc.contributor.authorSatake, Susan [UNIFESP]
dc.contributor.authorPerry, Juliana Cini [UNIFESP]
dc.contributor.authorGarcia, Karina de Oliveira [UNIFESP]
dc.contributor.authorD'Almeida, Vânia [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorLongo, Beatriz Monteiro [UNIFESP]
dc.contributor.authorSilva, Regina Cláudia Barbosa da [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:47:10Z
dc.date.available2015-06-14T13:47:10Z
dc.date.issued2014-06-01
dc.description.abstractThe present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifespUNIFESP
dc.description.provenanceMade available in DSpace on 2015-06-14T13:47:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-01. Added 1 bitstream(s) on 2015-08-11T04:04:14Z : No. of bitstreams: 1 S1983-32882014000200008.pdf: 1420081 bytes, checksum: a238af4fd734d6bcf1a0fb96acf22c5d (MD5)en
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2006/61223-3pt
dc.description.sponsorshipIDFAPESP: 2009/07278-9pt
dc.description.sponsorshipIDFAPESP: 2009/07347-0pt
dc.description.sponsorshipIDFAPESP: 2009/03616-7pt
dc.description.sponsorshipIDFAPESP: 2010/00120-8pt
dc.description.sponsorshipIDCEPID: 98/14303-3pt
dc.format.extent125-130
dc.identifierhttps://dx.doi.org/10.3922/j.psns.2014.02.03
dc.identifier.citationPsychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014.
dc.identifier.doi10.3922/j.psns.2014.02.03
dc.identifier.fileS1983-32882014000200008.pdf
dc.identifier.issn1983-3288
dc.identifier.scieloS1983-32882014000200008
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/8453
dc.language.isoeng
dc.publisherPontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo
dc.relation.ispartofPsychology & Neuroscience
dc.rightsAcesso aberto
dc.subjectHypoxiaen
dc.subjectNeurodevelopmenten
dc.subjectHyperactivityen
dc.subjectCell survivalen
dc.subjectSchizophreniaen
dc.titleEffect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthooden
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