Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
Carregando...
Data
2014-06-01
Autores
Yamada, Karen Yukie [UNIFESP]
Satake, Susan [UNIFESP]
Perry, Juliana Cini [UNIFESP]
Garcia, Karina de Oliveira [UNIFESP]
D'Almeida, Vânia [UNIFESP]
Tufik, Sergio [UNIFESP]
Longo, Beatriz Monteiro [UNIFESP]
Silva, Regina Cláudia Barbosa da [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.
Descrição
Citação
Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014.