Treatment of moderate obstructive sleep apnea syndrome with acupuncture: A randomised, placebo-controlled pilot trial
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2007-01-01
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Freire, Anaflavia de Oliveira 
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Background and purpose: To investigate the efficacy of acupuncture in the treatment of moderate obstructive sleep apnea syndrome (OSAS), assessed by polysomnography (PSG) and questionnaires of functional quality of life (SF-36) and excessive daytime sleepiness (Epworth).Patients and methods: We performed a randomised, placebo-controlled, single-blinded study, with blinded evaluation on 36 patients presenting an apnea/hypopnea index (AHI) of 15-30/h, assessed by PSG. the study took place at the Public Hospital of the Universidade Federal de S (a) over tildeo Paulo, Brazil, in the Division of Sleep Disorders of the Department of Psychobiology, between January, 2002 and August, 2004. Patients were randomly assigned to three groups: the acupuncture group (n = 12); the sham group, submitted to needle insertion in non-acupoints (n = 12); and the control group, receiving no treatment (n = 12). Patients received acupuncture or sham acupuncture once a week for 10 weeks.Results: Twenty-six patients completed the study. the AHI (P = 0.005), the apnea index (AI) (P = 0.008) and the number of respiratory events (P = 0.005) decreased significantly in the acupuncture group but not in the sham group. On the other hand, the control group displayed significant deterioration in some of the polysomnographic parameters, with a significant increase in the n umber of respiratory events (P = 0.025). Acupuncture treatment significantly improved (before vs. after treatment) several dimensions of the SF-36 and Epworth questionnaires. There was no significant association between changes in the body mass index (BMI) and AHI.Conclusions: Acupuncture is more effective than sharn acupuncture in ameliorating the respiratory events of patients presenting with moderate OSAS. (c) 2006 Elsevier B.V. All rights reserved.
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Sleep Medicine. Amsterdam: Elsevier B.V., v. 8, n. 1, p. 43-50, 2007.