Interações entre benzodiazepínicos e etanol: uma revisão bibliográfica
Data
2024-08-22
Autores
Alcântara, Deane Caroline 
Orientadores
Garcia, Raphael Caio Tamborelli
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Este estudo teve como objetivo avaliar diversas interações entre o etanol e benzodiazepínicos relatadas entre os anos 2003-2023. Foram utilizados os termos de busca "Ethanol"[Mesh],"Benzodiazepines"[Mesh] e "Drug Interactions"[Mesh]", o operador booleano “AND” foi utilizado para combinar os termos de pesquisa, na base de dados PubMed e, após a leitura do título e resumo, foram incluídos 24 artigos que contemplavam os seguintes critérios: (i) resumo citando interação entre algum benzodiazepínico e etanol e (ii) estudos in vivo e in vitro relatando interações. Após a leitura completa destes, apenas 12 foram utilizados na discussão deste trabalho. A exclusão do restante se deu por 3 critérios: (i) não relacionar os benzodiazepínicos com o etanol e vice versa, relacionando apenas um deles com outra condição, como exemplo a ansiedade, (ii) avaliar os efeitos individuais dos benzodiazepínicos ou do etanol nos receptores individualmente e (iii) artigo não disponível. As alterações farmacocinéticas descritas envolvem tanto a alteração da biotransformação de fármacos quanto do álcool quando há a coadministração das substâncias. Os efeitos farmacodinâmicos e comportamentais foram avaliados de várias formas, como alteração no efeito anticonvulsivante, miorrelaxante, efeitos na memória, intensificação de efeito reforçador, tanto de animais quanto de seres humanos, e avaliação de interações entre o benzodiazepínico e o etanol em casos post-mortem nos quais a causa da morte foi intoxicação por um deles ou por ambos. Todos os estudos apontam interações entre o benzodiazepínico e o etanol, mesmo com significância baixa. Avalia-se que o estudo dessas interações são extremamente importantes, visto que os benzodiazepínicos são altamente consumidos pela população, com ou sem prescrição médica e orientação adequada, principalmente quando há a utilização concomitante de etanol na vigência do tratamento medicamentoso, podendo desencadear reações inesperadas, devido a intensificação do efeito dos fármacos quando se há a ingestão de bebidas alcoólicas.
This study aimed to evaluate several interactions between ethanol and benzodiazepines reported between the years 2003-2023. The search terms "Ethanol"[Mesh], "Benzodiazepines"[Mesh] and "Drug Interactions"[Mesh] were used, the boolean operator “AND” was used to combine the search terms in the PubMed and after reading the title and abstract, 24 articles were included that met the following criteria: (i) abstract citing interaction between some benzodiazepine and ethanol and (ii) studies alive It is in vitro reporting interactions. After reading them completely, only 12 were used in the discussion of this work. The exclusion of the remainder was based on 3 criteria: (i) not relating benzodiazepines to ethanol and vice versa, relating only one of them to another condition, such as anxiety, (ii) evaluating the individual effects of benzodiazepines or ethanol on recipients individually and (iii) article not available. The pharmacokinetic changes described involve both the alteration of drug biotransformation How much alcohol when the substances are co-administered. The pharmacodynamic and behavioral effects were evaluated in several ways, such as changes in the anticonvulsant and myorelaxant effects, effects on memory, intensification of the reinforcing effect, both in animals and humans, and evaluation of interactions between benzodiazepine and ethanol in cases post-mortem in which the cause of death was poisoning by one or both of them. All studies point to interactions between benzodiazepines and ethanol, even with low significance. It is considered that the study of these interactions is extremely important, since benzodiazepines are highly consumed by the population, with or without a medical prescription and adequate guidance, especially when there is concomitant use of ethanol during drug treatment, which can trigger unexpected reactions, due to the intensification of the effect of drugs when alcoholic beverages are consumed.
This study aimed to evaluate several interactions between ethanol and benzodiazepines reported between the years 2003-2023. The search terms "Ethanol"[Mesh], "Benzodiazepines"[Mesh] and "Drug Interactions"[Mesh] were used, the boolean operator “AND” was used to combine the search terms in the PubMed and after reading the title and abstract, 24 articles were included that met the following criteria: (i) abstract citing interaction between some benzodiazepine and ethanol and (ii) studies alive It is in vitro reporting interactions. After reading them completely, only 12 were used in the discussion of this work. The exclusion of the remainder was based on 3 criteria: (i) not relating benzodiazepines to ethanol and vice versa, relating only one of them to another condition, such as anxiety, (ii) evaluating the individual effects of benzodiazepines or ethanol on recipients individually and (iii) article not available. The pharmacokinetic changes described involve both the alteration of drug biotransformation How much alcohol when the substances are co-administered. The pharmacodynamic and behavioral effects were evaluated in several ways, such as changes in the anticonvulsant and myorelaxant effects, effects on memory, intensification of the reinforcing effect, both in animals and humans, and evaluation of interactions between benzodiazepine and ethanol in cases post-mortem in which the cause of death was poisoning by one or both of them. All studies point to interactions between benzodiazepines and ethanol, even with low significance. It is considered that the study of these interactions is extremely important, since benzodiazepines are highly consumed by the population, with or without a medical prescription and adequate guidance, especially when there is concomitant use of ethanol during drug treatment, which can trigger unexpected reactions, due to the intensification of the effect of drugs when alcoholic beverages are consumed.