Gomesin acts in the immune system and promotes myeloid differentiation and monocyte/macrophage activation in mouse

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dc.citation.volume85
dc.contributor.authorBuri, Marcus Vinicius [UNIFESP]
dc.contributor.authorDias, Carolina Carvalho [UNIFESP]
dc.contributor.authorBarbosa, Christiano Marcello Vaz [UNIFESP]
dc.contributor.authorNogueira-Pedro, Amanda [UNIFESP]
dc.contributor.authorRibeiro-Filho, Antonio C.
dc.contributor.authorMiranda, Antonio [UNIFESP]
dc.contributor.authorParedes-Gamero, Edgar Julian [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-31T12:47:29Z
dc.date.available2020-07-31T12:47:29Z
dc.date.issued2016
dc.description.abstractDue to the cytotoxic effect of antimicrobial peptides (AMP) against several microorganism and tumor cells has been proposed their association with the immune system. However, just a few reports have shown this relationship. In this study, mice were treated with gomesin, a beta-hairpin AMP that exhibit high cytotoxicity against bacterial and tumor cells. Different effects in the immune system were observed, such as, decrease of CD3(+) in T lymphocytes (Control: 17.7 +/- 1.4%en
dc.description.abstractGomesin: 7.67 +/- 11.2%) and in hematopoietic progenitors and increase of hematopoietic stem cell (Control: 0.046 +/- 0.004%en
dc.description.abstractGomesin: 0.067 +/- 10.003%), B220(+) B lymphocytes (Control: 38.63 +/- 1.5%en
dc.description.abstractGomesin: 47.83 +/- 0.48%), and Mac-1(+)F4/80(+) macrophages (Control: 11.76 +/- 3.4%en
dc.description.abstractGomesin: 27.13 +/- 4.0%). Additionally, macrophage increase was accompanied by an increase of macrophage phagocytosis (Control 20.85 +/- 1.53en
dc.description.abstractGomesin 31.32 +/- 1 Geometric mean), interleukin 6 (Control: 47.24 +/- 1.9 ng/mLen
dc.description.abstractGomesin: 138.68 +/- 33.68 ng/mL) and monocyte chemoattractant protein-1 (Control: 0.872 +/- 0.093 ng/mLen
dc.description.abstractGomesin: 1.83 +/- 0.067 ng/mL). Thus, this report showed immunomodulatory activity of gomesin in the immune system of mice. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Bioquim, R Tres Maio 100, BR-04044020 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biofis, R Tres Maio 100, BR-04044020 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquirm, Av Dr Candido Xavier Almeida Souza 200, Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUnifespDepartamento de Bioquímica, Universidade Federal de São Paulo, R. Três de Maio 100, 04044-020, São Paulo, SP, Brazil
dc.description.affiliationUnifespDepartamento de Biofísica, Universidade Federal de São Paulo, R. Três de Maio 100, 04044-020, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipINFAR/UNIFESP Confocal and Flow Cytometry Facility
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2013/09068-7
dc.description.sponsorshipIDFAPESP: 2011/17584-0
dc.description.sponsorshipIDCNPq: 473797/2013-5
dc.description.sponsorshipIDFAPESP: 2012/20989-4
dc.description.sponsorshipIDFAPESP: 2015/22901-5
dc.format.extent41-45
dc.identifierhttp://dx.doi.org/10.1016/j.peptides.2016.09.003
dc.identifier.citationPeptides. New York, v. 85, p. 41-45, 2016.
dc.identifier.doi10.1016/j.peptides.2016.09.003
dc.identifier.issn0196-9781
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56854
dc.identifier.wosWOS:000387299200004
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofPeptides
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobial peptideen
dc.subjectGomesinen
dc.subjectImmunomodulatory activityen
dc.subjectMacrophage activationen
dc.titleGomesin acts in the immune system and promotes myeloid differentiation and monocyte/macrophage activation in mouseen
dc.typeinfo:eu-repo/semantics/article
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