Gomesin acts in the immune system and promotes myeloid differentiation and monocyte/macrophage activation in mouse
Data
2016
Autores
Buri, Marcus Vinicius 
Dias, Carolina Carvalho
Barbosa, Christiano Marcello Vaz
Nogueira-Pedro, Amanda
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Due to the cytotoxic effect of antimicrobial peptides (AMP) against several microorganism and tumor cells has been proposed their association with the immune system. However, just a few reports have shown this relationship. In this study, mice were treated with gomesin, a beta-hairpin AMP that exhibit high cytotoxicity against bacterial and tumor cells. Different effects in the immune system were observed, such as, decrease of CD3(+) in T lymphocytes (Control: 17.7 +/- 1.4%
Gomesin: 7.67 +/- 11.2%) and in hematopoietic progenitors and increase of hematopoietic stem cell (Control: 0.046 +/- 0.004%
Gomesin: 0.067 +/- 10.003%), B220(+) B lymphocytes (Control: 38.63 +/- 1.5%
Gomesin: 47.83 +/- 0.48%), and Mac-1(+)F4/80(+) macrophages (Control: 11.76 +/- 3.4%
Gomesin: 27.13 +/- 4.0%). Additionally, macrophage increase was accompanied by an increase of macrophage phagocytosis (Control 20.85 +/- 1.53
Gomesin 31.32 +/- 1 Geometric mean), interleukin 6 (Control: 47.24 +/- 1.9 ng/mL
Gomesin: 138.68 +/- 33.68 ng/mL) and monocyte chemoattractant protein-1 (Control: 0.872 +/- 0.093 ng/mL
Gomesin: 1.83 +/- 0.067 ng/mL). Thus, this report showed immunomodulatory activity of gomesin in the immune system of mice. (C) 2016 Elsevier Inc. All rights reserved.
Gomesin: 7.67 +/- 11.2%) and in hematopoietic progenitors and increase of hematopoietic stem cell (Control: 0.046 +/- 0.004%
Gomesin: 0.067 +/- 10.003%), B220(+) B lymphocytes (Control: 38.63 +/- 1.5%
Gomesin: 47.83 +/- 0.48%), and Mac-1(+)F4/80(+) macrophages (Control: 11.76 +/- 3.4%
Gomesin: 27.13 +/- 4.0%). Additionally, macrophage increase was accompanied by an increase of macrophage phagocytosis (Control 20.85 +/- 1.53
Gomesin 31.32 +/- 1 Geometric mean), interleukin 6 (Control: 47.24 +/- 1.9 ng/mL
Gomesin: 138.68 +/- 33.68 ng/mL) and monocyte chemoattractant protein-1 (Control: 0.872 +/- 0.093 ng/mL
Gomesin: 1.83 +/- 0.067 ng/mL). Thus, this report showed immunomodulatory activity of gomesin in the immune system of mice. (C) 2016 Elsevier Inc. All rights reserved.
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Peptides. New York, v. 85, p. 41-45, 2016.