Alterações imunológicas e respostas inflamatórias ao uso de um blend nutricional em atletas de crossfit: estudo clínico controlado randomizado
Data
2024-08-16
Autores
Ferreira, Ricardo Cesar Alves 
Orientadores
Vieira, Rodolfo de Paula
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Introdução: A acumulação excessiva de cargas de treinamento pode resultar em queda de performance e estar associada à síndrome do overtraining, caracterizada por sintomas como fadiga física e mental, lesões, maior suscetibilidade a infecções, insônia, falta de apetite, inflamação crônica e dores. Investigar a resposta inflamatória e imunológica frente ao exercício intenso é fundamental para entender o papel da suplementação na relação estímulo-recuperação. O uso de suplementos alimentares tem sido explorado como uma possível estratégia para potencializar a recuperação de atletas. Objetivos: Avaliar a eficácia de um blend nutricional como alternativa para minimizar os prejuízos causados pela rotina de treinamentos intensos e melhorar a recuperação de atletas de Crossfit®. Como objetivo secundário, investigar a possível relação entre os quadros inflamatórios e a queda de desempenho, por meio da mensuração da força neuromuscular. Métodos: Foram recrutados 67 atletas, de ambos os sexos, com idades entre 18 e 45 anos, praticantes de treinamento de modalidade mista (Mixed Modality Training - MMT), também conhecido como Crossfit®, que se caracteriza por exercícios de alta demanda fisiológica. Os participantes foram divididos em dois grupos: Grupo ImmuneRecov (IR), composto por 37 atletas que receberam o suplemento nutricional, e Grupo Controle (CON), composto por 30 atletas que receberam um placebo. Os participantes foram submetidos a 30 dias de treino e realizaram avaliações em dois momentos: no início e ao final do período. Resultados: O grupo suplementado com o blend nutricional apresentou menores valores de neutrófilos, enquanto outras células imunológicas não mostraram diferenças significativas entre os grupos. Os marcadores IL-10 e IGF-1 apresentaram aumentos significativos, enquanto IL-1β mostrou redução no grupo suplementado em comparação ao grupo controle. A capacidade de produção de força neuromuscular aumentou em ambos os grupos. Conclusão: A suplementação com ImmuneRecov® demonstrou melhor desempenho em relação ao placebo para marcadores como neutrófilos, IGF-1 e IL-10, o que pode indicar um facilitador no processo de recuperação pós-treino. Embora os resultados sejam promissores, a implementação do ImmuneRecov® como uma intervenção para aprimorar a performance esportiva deve ser considerada com cautela e avaliada em estudos futuros mais amplos e detalhados.
Introduction: The accumulation of excessive training loads can result in decreased performance and may be associated with overtraining syndrome, characterized by symptoms such as physical and mental fatigue, injuries, increased susceptibility to infections, insomnia, loss of appetite, chronic inflammation, and pain. Investigating the inflammatory and immune response to intense exercise is essential to understand the role of supplementation in the stimulus-recovery relationship. The use of dietary supplements has been explored as a possible strategy to enhance athlete recovery. Objectives: To evaluate the effectiveness of a nutritional blend as an alternative to mitigate the negative impacts caused by intense training routines and to enhance recovery in Crossfit® athletes. A secondary objective was to investigate the possible relationship between inflammatory conditions and performance decline by measuring neuromuscular strength. Methods: A total of 67 male and female athletes aged 18 to 47 years, practicing Mixed Modality Training (MMT), also known as Crossfit®, a modality characterized by high physiological demands, were recruited. The participants were divided into two groups: the ImmuneRecov (IR) group, consisting of 37 athletes who received the nutritional supplement, and the Control group (CON), consisting of 30 athletes who received a placebo. The athletes underwent 30 days of training and were evaluated at two points: at the beginning and after 30 days. Results: The supplemented group showed lower levels of neutrophils, while other immune cells showed no significant differences between the groups. The markers IL-10 and IGF-1 showed significant increases, while IL-1β levels were lower in the supplemented group compared to the control. Neuromuscular strength production capacity increased in both groups. Conclusion: Supplementation with ImmuneRecov® demonstrated better performance compared to the placebo for markers such as neutrophils, IGF-1, and IL10, which may indicate a facilitative role in the post-exercise recovery process. Although the results are promising, the use of ImmuneRecov® as an intervention to enhance athletic performance should be approached with caution and evaluated in more extensive and detailed future studies.
Introduction: The accumulation of excessive training loads can result in decreased performance and may be associated with overtraining syndrome, characterized by symptoms such as physical and mental fatigue, injuries, increased susceptibility to infections, insomnia, loss of appetite, chronic inflammation, and pain. Investigating the inflammatory and immune response to intense exercise is essential to understand the role of supplementation in the stimulus-recovery relationship. The use of dietary supplements has been explored as a possible strategy to enhance athlete recovery. Objectives: To evaluate the effectiveness of a nutritional blend as an alternative to mitigate the negative impacts caused by intense training routines and to enhance recovery in Crossfit® athletes. A secondary objective was to investigate the possible relationship between inflammatory conditions and performance decline by measuring neuromuscular strength. Methods: A total of 67 male and female athletes aged 18 to 47 years, practicing Mixed Modality Training (MMT), also known as Crossfit®, a modality characterized by high physiological demands, were recruited. The participants were divided into two groups: the ImmuneRecov (IR) group, consisting of 37 athletes who received the nutritional supplement, and the Control group (CON), consisting of 30 athletes who received a placebo. The athletes underwent 30 days of training and were evaluated at two points: at the beginning and after 30 days. Results: The supplemented group showed lower levels of neutrophils, while other immune cells showed no significant differences between the groups. The markers IL-10 and IGF-1 showed significant increases, while IL-1β levels were lower in the supplemented group compared to the control. Neuromuscular strength production capacity increased in both groups. Conclusion: Supplementation with ImmuneRecov® demonstrated better performance compared to the placebo for markers such as neutrophils, IGF-1, and IL10, which may indicate a facilitative role in the post-exercise recovery process. Although the results are promising, the use of ImmuneRecov® as an intervention to enhance athletic performance should be approached with caution and evaluated in more extensive and detailed future studies.
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Citação
FERREIRA, Ricardo Cesar Alves. Alterações imunológicas e respostas inflamatórias ao uso de um blend nutricional em atletas de crossfit: estudo clínico controlado randomizado. 2024. 48 f. Tese (Doutorado em Ciências do Movimento Humano e Reabilitação) - Universidade Federal de São Paulo, Instituto de Saúde e Sociedade, Santos, 2024.