beta-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios

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dc.citation.issue2
dc.citation.volume18
dc.contributor.authorRibeiro, Camilla M. [UNIFESP]
dc.contributor.authorSilva, Erick J. R. [UNIFESP]
dc.contributor.authorHinton, Barry T.
dc.contributor.authorAvellar, Maria Christina W. [UNIFESP]
dc.coverageMumbai
dc.date.accessioned2020-08-21T17:00:17Z
dc.date.available2020-08-21T17:00:17Z
dc.date.issued2016
dc.description.abstractbeta-defensins are components of host defense, with antimicrobial and pleiotropic immuno-modulatory properties. Research over the last 15 years has demonstrated abundant expression of a variety of -defensins in the postnatal epididymis of different species. A gradient of region- and cell-specific expression of these proteins is observed in the epithelium of the postnatal epididymis. Their secretion into the luminal fluid and binding to spermatozoa as they travel along the epididymis has suggested their involvement in reproduction-specific tasks. Therefore, continuous attention has been given to various -defensins for their role in sperm function and fertility. Although -defensins are largely dependent on androgens, the underlying mechanisms regulating their expression and function in the epididymis are not well understood. Recent investigation has pointed out to a new and interesting scenario where -defensins emerge with a different expression pattern in the Wolffian duct, the embryonic precursor of the epididymis, as opposed to the adult epididymis, thereby redefining the concept concerning the multifunctional roles of -defensins in the developing epididymis. In this review, we summarize some current views of -defensins in the epididymis highlighting our most recent data and speculations on their role in the developing epididymis during the prenatal-to-postnatal transition, bringing attention to the many unanswered questions in this research area that may contribute to a better understanding of epididymal biology and male fertility.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, Sao Paulo, Brazil
dc.description.affiliationUniv Virginia, Sch Med, Dept Cell Biol, Charlottesville, VA 22908 USA
dc.description.affiliationUniv Estadual Paulista, Dept Pharmacol, Inst Biosci Botucatu, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCNPq/Science Without Borders
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipNational Institutes of Health Eunice Kennedy Shriver NICHD
dc.description.sponsorshipIDCNPq: 480452/2008-3
dc.description.sponsorshipIDCNPq: 455450/2014-5
dc.description.sponsorshipIDCNPq: 308349/2010-5
dc.description.sponsorshipIDCNPq/Science Without Borders: PVE401932/2013-3
dc.description.sponsorshipIDCNPq/Science Without Borders: 167292-2013-7
dc.description.sponsorshipIDCNPq/Science Without Borders: 401718/2012-3
dc.description.sponsorshipIDCAPES: 02921/09-2
dc.description.sponsorshipIDFAPESP: 2010/52711-0
dc.description.sponsorshipIDFAPESP: 2009/14649-3
dc.description.sponsorshipIDNational Institutes of Health Eunice Kennedy Shriver NICHD: HD069654
dc.description.sponsorshipIDNational Institutes of Health Eunice Kennedy Shriver NICHD: HD068365
dc.format.extent323-328
dc.identifierhttp://dx.doi.org/10.4103/1008-682X.168791
dc.identifier.citationAsian Journal Of Andrology. Mumbai, v. 18, n. 2, p. 323-328, 2016.
dc.identifier.doi10.4103/1008-682X.168791
dc.identifier.fileWOS000370293900033.pdf
dc.identifier.issn1008-682X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57927
dc.identifier.wosWOS:000370293900033
dc.language.isoeng
dc.publisherMedknow Publications & Media Pvt Ltd
dc.relation.ispartofAsian Journal Of Andrology
dc.rightsAcesso aberto
dc.subjectandrogensen
dc.subjectembryogenesisen
dc.subjectepididymisen
dc.subjectorganogenesisen
dc.subjectbeta-defensinsen
dc.titlebeta-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenariosen
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