Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates

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dc.citation.volume77
dc.contributor.authorChudzinski-Tavassi, Ana Marisa
dc.contributor.authorMorais, Katia L. P. [UNIFESP]
dc.contributor.authorPacheco, Mario Thiego Fernandes
dc.contributor.authorPasqualoto, Kerly Fernanda Mesquita
dc.contributor.authorde Souza, Jean Gabriel [UNIFESP]
dc.coverageIssy-Les-Moulineaux
dc.date.accessioned2020-11-03T14:40:38Z
dc.date.available2020-11-03T14:40:38Z
dc.date.issued2016
dc.description.abstractNowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its saliva has a very rich variety of bioactive molecules. For instance, a Kunitz-type FXa inhibitor, named Amblyomin-X, was found through transcriptome of the salivary gland of the Amblyomma cajennense. tick. This TFPI-like inhibitor, after obtained as recombinant protein, has presented anticoagulant, antigionenic, and antitumor properties. Although its effects on blood coagulation could be relevant for antitumor effect, Amblyomin-X acts by non-hemostatic mechanisms, such as proteasome inhibition and autophagy inhibition. Notably, cytotoxicity was not observed on non-tumor cells treated with this protein, suggesting some selectivity for tumor cells. Considering the current efforts in order to develop effective anticancer therapies, the findings presented in this review strongly suggest Amblyomin-X as a promising novel antitumor drug candidate. (C) 2015 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationButantan Inst, Biochem & Biophys Lab, BR-05503900 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipIDFAPESP: 2010/52669-3
dc.description.sponsorshipIDFAPESP: 2010/07958-7
dc.description.sponsorshipIDFAPESP: 2011/05969-4
dc.description.sponsorshipIDFAPESP CAT/CEPID: 1998/14307-9
dc.description.sponsorshipIDFAPESP CETICs: 2013/07467-1
dc.format.extent14-19
dc.identifierhttps://doi.org/10.1016/j.biopha.2015.11.003
dc.identifier.citationBiomedicine & Pharmacotherapy. Issy-Les-Moulineaux, v. 77, p. 14-19, 2016.
dc.identifier.doi10.1016/j.biopha.2015.11.003
dc.identifier.issn0753-3322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58655
dc.identifier.wosWOS:000368104100003
dc.language.isoeng
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsAcesso restrito
dc.subjectAmblyomin-Xen
dc.subjectTFPI-likeen
dc.subjectProteasome inhibitoren
dc.subjectAutophagy inhibitionen
dc.subjectAntitumor drug candidateen
dc.subjectAnticoagulanten
dc.titleTick salivary gland as potential natural source for the discovery of promising antitumor drug candidatesen
dc.typeArtigo
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