Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates
Data
2016
Autores
Morais, Katia L. P. 
de Souza, Jean Gabriel
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its saliva has a very rich variety of bioactive molecules. For instance, a Kunitz-type FXa inhibitor, named Amblyomin-X, was found through transcriptome of the salivary gland of the Amblyomma cajennense. tick. This TFPI-like inhibitor, after obtained as recombinant protein, has presented anticoagulant, antigionenic, and antitumor properties. Although its effects on blood coagulation could be relevant for antitumor effect, Amblyomin-X acts by non-hemostatic mechanisms, such as proteasome inhibition and autophagy inhibition. Notably, cytotoxicity was not observed on non-tumor cells treated with this protein, suggesting some selectivity for tumor cells. Considering the current efforts in order to develop effective anticancer therapies, the findings presented in this review strongly suggest Amblyomin-X as a promising novel antitumor drug candidate. (C) 2015 Elsevier Masson SAS. All rights reserved.
Descrição
Citação
Biomedicine & Pharmacotherapy. Issy-Les-Moulineaux, v. 77, p. 14-19, 2016.