Distinct Gender-related Sleep Pattern in an Acute Model of TMJ Pain

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dc.contributor.authorSchutz, T. C. B. [UNIFESP]
dc.contributor.authorAndersen, M. L. [UNIFESP]
dc.contributor.authorSilva, A. [UNIFESP]
dc.contributor.authorTufik, S. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:32Z
dc.date.available2016-01-24T13:52:32Z
dc.date.issued2009-05-01
dc.description.abstractSince it is recognized that acute inflammation of the temporomandibular joint results in sleep disturbances in male rats, and that the orofacial region may display a site-specific effect of ovarian hormones on nociception, we hypothesized that distinct genders would respond differently when subjected to this inflammatory acute orofacial pain. Sleep was monitored after injection of saline/Freund's adjuvant into the temporomandibular joint in male and female (proestrus and diestrus phases) rats. Progesterone and stress-related hormones were also assessed. in males, Freund's adjuvant induced a significant nociceptive response and sleep disturbances. Behavior and sleep architecture in the females remained unaffected. Our results suggest that females and males present distinct responses to an acute model of orofacial pain.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCEPID
dc.description.sponsorshipIDFAPESP: 07/56620-6
dc.description.sponsorshipIDCEPID: 98/14303-3
dc.format.extent471-476
dc.identifierhttp://dx.doi.org/10.1177/0022034509334618
dc.identifier.citationJournal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 88, n. 5, p. 471-476, 2009.
dc.identifier.doi10.1177/0022034509334618
dc.identifier.issn0022-0345
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31513
dc.identifier.wosWOS:000266624600015
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Dental Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjecttemporomandibular jointen
dc.subjectorofacial painen
dc.subjectsleepen
dc.subjectgendersen
dc.subjectfemale ratsen
dc.subjectestrous cycleen
dc.titleDistinct Gender-related Sleep Pattern in an Acute Model of TMJ Painen
dc.typeinfo:eu-repo/semantics/article
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