Distinct Gender-related Sleep Pattern in an Acute Model of TMJ Pain
Data
2009-05-01
Autores
Schutz, T. C. B. 
Andersen, M. L.
Silva, A.
Tufik, S.
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Since it is recognized that acute inflammation of the temporomandibular joint results in sleep disturbances in male rats, and that the orofacial region may display a site-specific effect of ovarian hormones on nociception, we hypothesized that distinct genders would respond differently when subjected to this inflammatory acute orofacial pain. Sleep was monitored after injection of saline/Freund's adjuvant into the temporomandibular joint in male and female (proestrus and diestrus phases) rats. Progesterone and stress-related hormones were also assessed. in males, Freund's adjuvant induced a significant nociceptive response and sleep disturbances. Behavior and sleep architecture in the females remained unaffected. Our results suggest that females and males present distinct responses to an acute model of orofacial pain.
Descrição
Citação
Journal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 88, n. 5, p. 471-476, 2009.