Fatores associados à hipovitaminose D na doença renal crônica

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dc.contributor.advisorKamimura, Maria Ayako [UNIFESP]
dc.contributor.authorFiguiredo-Dias, Vilani [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-12-06T23:03:33Z
dc.date.available2015-12-06T23:03:33Z
dc.date.issued2011
dc.description.abstractBackground: Hypovitaminosis D is highly prevalent among chronic kidney disease patients and it has been associated with worse outcome even in the earlier stages of the disease. Objective: This study aimed to investigate the risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. Design: This cross-sectional study included 120 chronic kidney disease patients on stages 2 to 5 (62% male, age 55.4±11.3yr, estimated glomerular filtration rate 35.1±15ml/min, body mass index (BMI) 27.1±5.2kg/m2, 31% diabetics). Serum 25-hydroxivitamin D was measured by chemiluminescence. Subjective global assessment, total body fat (dual-energy X-ray absorptiometry), visceral and subcutaneous abdominal fat (computed tomography) and several laboratory parameters were assessed. Results: Insufficiency of 25-hydroxivitamin D (15-30ng/ml) was observed in 55% of the patients and deficiency (<15ng/ml) in 20%. Patients with diabetes, BMI ≥30kg/m2, and who had the blood collection during the winter or spring had lower 25-hydroxivitamin D levels. Serum 25-hydroxivitamin D correlated inversely with parathyroid hormone, proteinuria, insulin resistance, leptin, and subcutaneous abdominal fat. The risk factors for hypovitaminosis D were diabetes (odds ratio 3.8; 95% CI 1.2-11.7; P=0.022) and BMI ≥30kg/m2 (odds ratio 4.3; 95% CI 1.2-15.3; P=0.018). In the logistic regression analysis adjusting for gender, skin color and season of the year, diabetes and BMI ≥30kg/m2 were independently associated with hypovitaminosis D. Conclusions: Diabetes and obesity were the risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. Effective interventional protocols of vitamin D supplementation taking into account these risk factors are warranted for this population.en
dc.description.sourceBV UNIFESP: Teses e dissertações
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação Oswaldo Ramos
dc.format.extent103 f.
dc.identifier.citationFIGUIREDO-DIAS, Vilani. Fatores associados à hipovitaminose D na doença renal crônica. 2011. 103 f. Dissertação (Mestrado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2011.
dc.identifier.fileTese-12405.pdf
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/19159
dc.language.isopor
dc.publisherUniversidade Federal de São Paulo (UNIFESP)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDeficiência de Vitaminaspt
dc.subjectDeficiência de Vitamina Dpt
dc.subjectDiabetes Mellituspt
dc.subjectObesidadept
dc.subjectDoença Crônicapt
dc.subjectRim/patologiapt
dc.subjectHypovitaminosis Den
dc.subject25-hydroxivitamin Den
dc.subjectDiabetesen
dc.subjectObesityen
dc.subjectChronic kidney disease.en
dc.titleFatores associados à hipovitaminose D na doença renal crônicapt
dc.title.alternativeFactors associated with vitamin D deficiency in chronic kidney diseaseen
dc.typeinfo:eu-repo/semantics/masterThesis
unifesp.campusSão Paulo, Escola Paulista de Medicina (EPM)pt
unifesp.graduateProgramNutrição - EPM
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