Prevalência de osteonecrose e fatores associados à sua manifestação em uma coorte de portadores de doença falciforme
Data
2024-09-06
Orientadores
Figueiredo, Maria Stella 
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
A osteonecrose é uma complicação comum e debilitante da doença falciforme, caracterizada pela morte do tecido ósseo devido à interrupção do suprimento sanguíneo. OBJETIVO: Este estudo teve como objetivo avaliar características genotípicas e laboratoriais associadas à manifestação de osteonecrose em um grupo de portadores de doença falciforme. MÉTODOS: Foi realizada uma análise transversal em uma amostra de 307 pacientes com diagnóstico confirmado de doença falciforme, acompanhados no Ambulatório de Anemias Hereditárias da Escola Paulista de Medicina/UNIFESP. Nesse estudo foram coletados e analisados dados clínicos e laboratoriais de modo retrospectivo e longitudinal. A prevalência de osteonecrose foi determinada, e análise multivariada foi realizada para identificar os fatores de risco associados à condição. RESULTADOS E DISCUSSÃO: Os resultados mostraram que a prevalência de osteonecrose na coorte foi de 35%, sem diferença de prevalência entre os grupos estudados. Entre os fatores associados à maior incidência de osteonecrose, destacaram-se níveis de hemoglobina, relação hemoglobina/hematócrito e contagem de glóbulos brancos, neutrófilos e plaquetas. O uso de hidroxiureia não mostrou correlação com a manifestação de osteonecrose. CONCLUSÃO: Concluiu-se que a osteonecrose é uma complicação prevalente em pacientes com doença falciforme e parece estar associada a diversos fatores clínico- laboratoriais. Estes achados ressaltam a importância do monitoramento regular e da implementação de estratégias preventivas para minimizar o impacto da osteonecrose na qualidade de vida desses pacientes.
Osteonecrosis is a common and debilitating complication of sickle cell disease, characterized by the death of bone tissue due to interruption of blood supply. OBJECTIVE: This study aimed to evaluate genotypic and laboratory characteristics associated with the manifestation of osteonecrosis in a group of patients with sickle cell disease. METHODS: A cross-sectional analysis was carried out on a sample of 307 patients with a confirmed diagnosis of sickle cell disease, followed at the Hereditary Anemia Outpatient Clinic of the Escola Paulista de Medicina/UNIFESP. In this study, clinical and laboratory data were collected and analyzed retrospectively and longitudinally. The prevalence of osteonecrosis was determined, and multivariate analysis was performed to identify risk factors associated with the condition. RESULTS AND DISCUSSION: The prevalence of osteonecrosis in this cohort was 35%, with no difference between the groups studied. Factors associated with a higher incidence of osteonecrosis were hemoglobin levels, hemoglobin/hematocrit ratio, and white blood cell, neutrophil, and platelet counts. The use of hydroxyurea did not show a correlation with osteonecrosis manifestation. CONCLUSION: We concluded that osteonecrosis is a prevalent complication in patients with sickle cell disease and appears to be associated with several clinical and laboratory factors. These findings highlight the importance of regular monitoring and the implementation of preventive strategies to minimize the impact of osteonecrosis on the quality of life of these patients.
Osteonecrosis is a common and debilitating complication of sickle cell disease, characterized by the death of bone tissue due to interruption of blood supply. OBJECTIVE: This study aimed to evaluate genotypic and laboratory characteristics associated with the manifestation of osteonecrosis in a group of patients with sickle cell disease. METHODS: A cross-sectional analysis was carried out on a sample of 307 patients with a confirmed diagnosis of sickle cell disease, followed at the Hereditary Anemia Outpatient Clinic of the Escola Paulista de Medicina/UNIFESP. In this study, clinical and laboratory data were collected and analyzed retrospectively and longitudinally. The prevalence of osteonecrosis was determined, and multivariate analysis was performed to identify risk factors associated with the condition. RESULTS AND DISCUSSION: The prevalence of osteonecrosis in this cohort was 35%, with no difference between the groups studied. Factors associated with a higher incidence of osteonecrosis were hemoglobin levels, hemoglobin/hematocrit ratio, and white blood cell, neutrophil, and platelet counts. The use of hydroxyurea did not show a correlation with osteonecrosis manifestation. CONCLUSION: We concluded that osteonecrosis is a prevalent complication in patients with sickle cell disease and appears to be associated with several clinical and laboratory factors. These findings highlight the importance of regular monitoring and the implementation of preventive strategies to minimize the impact of osteonecrosis on the quality of life of these patients.
Descrição
Citação
ZAMBIANCO, Júlia Figuerôa. Prevalência de osteonecrose e fatores associados à sua manifestação em uma coorte de portadores de doença falciforme. 2024. 68 f. Dissertação (Mestrado em Hematologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP). São Paulo, 2024.