Environmental risk assessment of triclosan and ibuprofen in marine sediments using individual and sub-individual endpoints

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dc.citation.volume232
dc.contributor.authorPusceddu, Fabio Hermes
dc.contributor.authorChoueri, Rodrigo Brasil [UNIFESP]
dc.contributor.authorPereira, Camilo Dias Seabra [UNIFESP]
dc.contributor.authorCortez, Fernando Sanzi
dc.contributor.authorSantos, Dymes Rafael Alves dos
dc.contributor.authorMoreno, Beatriz Barbosa
dc.contributor.authorSantos, Aldo Ramos
dc.contributor.authorRogero, José Roberto
dc.contributor.authorCesar, Augusto [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-02T18:52:15Z
dc.date.available2020-07-02T18:52:15Z
dc.date.issued2018
dc.description.abstractThe guidelines for the Environmental Risk Assessment (ERA) of pharmaceuticals and personal care products (PPCP) recommend the use of standard ecotoxicity assays and the assessment of endpoints at the individual level to evaluate potential effects of PPCP on biota. However, effects at the sub-individual level can also affect the ecological fitness of marine organisms chronically exposed to PPCP. The aim of the current study was to evaluate the environmental risk of two PPCP in marine sediments: triclosan (TCS) and ibuprofen (IBU), using sub-individual and developmental endpoints. The environmental levels of TCS and IBU were quantified in marine sediments from the vicinities of the Santos submarine sewage outfall (Santos Bay, Sao Paulo, Brazil) at 15.14 and 49.0 ng g(-1), respectively. A battery (n = 3) of chronic bioassays (embryo-larval development) with a sea urchin (Lytechinus variegatus) and a bivalve (Perna perna) were performed using two exposure conditions: sediment-water interface and elutriates. Moreover, physiological stress through the Neutral Red Retention Time Assay (NRRT) was assessed in the estuarine bivalve Mytella charruana exposed to TCS and IBU spiked sediments. These compounds affected the development of L. variegatus and P. perna (75 ng g(-1) for TCS and 15 ng g(-1) for IBU), and caused a significant decrease in M. charruana lysosomal membrane stability at environmentally relevant concentrations (0.08 ng g(-1) for TCS and 0.15 ng g(-1) for IBU). Chemical and ecotoxicological data were integrated and the risk quotient estimated for TCS and IBU were higher than 1.0, indicating a high environmental risk of these compounds in sediments. These are the first data of sediment risk assessment of pharmaceuticals and personal care products of Latin America. In addition, the results suggest that the ERA based only on individual-level and standard toxicity tests may overlook other biological effects that can affect the health of marine organisms exposed to PPCP. (C) 2017 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Sao Paulo, Inst Pesquisas Energet & Nucl, Ctr Quim & Meio Ambiente, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Santa Cecilia, Lab Ecotoxicol, Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Mar, Campus Baixada Santista, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Mar, Campus Baixada Santista, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDCNPq: 481553/2012-6
dc.description.sponsorshipIDCNPq: 481358/2012-9
dc.description.sponsorshipIDCNPq: 305869/2013-2
dc.description.sponsorshipIDCNPq: 307074/2013-7
dc.description.sponsorshipIDCNPq: 308079/2015-9
dc.format.extent274-283
dc.identifierhttps://dx.doi.org/10.1016/j.envpol.2017.09.046
dc.identifier.citationEnvironmental Pollution. Oxford, v. 232, p. 274-283, 2018.
dc.identifier.doi10.1016/j.envpol.2017.09.046
dc.identifier.fileWOS000414881300029.pdf
dc.identifier.issn0269-7491
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53977
dc.identifier.wosWOS:000414881300029
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofEnvironmental Pollution
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEnvironmental risk assessmenten
dc.subjectPharmaceuticals and personal care productsen
dc.subjectMytella charruanaen
dc.subjectLytechinus variegatusen
dc.subjectPerna pernaen
dc.titleEnvironmental risk assessment of triclosan and ibuprofen in marine sediments using individual and sub-individual endpointsen
dc.typeinfo:eu-repo/semantics/article
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