Efeito da administração aguda de melatonina no desempenho em exercício fisico aeróbio: estudo randomizado, cruzado, duplo-cego e placebo controlado
Arquivos
Data
2024-12-04
Autores
Santos, Iago Diniz 
Orientadores
Antunes, Hanna Karen Moreira
Tipo
Tese de doutorado
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Introdução: A melatonina (MEL), um hormônio sincronizador cronobiológico secretado principalmente pela glândula pineal, com maior abundância durante o ciclo escuro, tem sido cada vez mais estudada além de seu papel na regulação do ciclo circadiano. A administração exógena desse hormônio, associada ao desempenho atlético, tem sido vinculada a diferentes efeitos, dado seu papel na regulação circadiana em vários tecidos, o que pode resultar em efeitos ergogênicos. No entanto, não há consenso na literatura sobre o impacto da suplementação aguda no desempenho em exercícios aeróbicos e na recuperação pós-exercício. Objetivos: Investigar o impacto da administração aguda de melatonina sobre o desempenho atlético em exercício físico aeróbio. Métodos: Em um estudo crossover, randomizado, controlado por placebo e duplo-cego, 13 indivíduos saudáveis e fisicamente ativos participaram de duas visitas experimentais à tarde, nas quais realizaram uma sessão de exercício aeróbico em uma esteira, consistindo em 20 minutos a 60% da Vpico, seguida por um teste de time trial de 1,5 km com suplementação aguda de MEL (10 mg) ou placebo. Durante o teste time trial foram coletados dados sobre o tempo, velocidade, frequência cardíaca e percepção subjetiva de esforço, a cada 300 metros. Amostras de sangue (Creatina Quinase e Lactato Desidrogenase) foram coletadas em cinco momentos: basal (BAS), imediatamente após o exercício moderado (MOD), imediatamente após o teste de time trial (TT), 30 minutos (REC) e 24 horas (24H) após a sessão de exercício. A escala de humor de Brunel foi aplicada durante os intervalos BAS, TT e REC. A temperatura corporal (TC), pressão arterial diastólica (PAD) e sistólica (PAS) foram medidas em BAS, 25 minutos após a suplementação (POST SUP), MOD, TT e REC. A escala QTR (qualidade de recuperação) foi avaliada apenas 24 horas após o protocolo. Resultados: A melatonina não impactou o desempenho no teste de time trial (p>0,05), nem outros parâmetros fisiológicos avaliados durante o teste. Entretanto, a pressão arterial diastólica após o teste de time trial foi menor na condição melatonina (p=0,03) (TT*MEL vs. TT*PLA). Conclusão: A administração aguda de 10 mg de melatonina, oferecida 30 minutos antes do exercício aeróbico, parece não impactar o desempenho atlético, mas controla positivamente os valores de PAD após o exercício aeróbico.
Introduction: Melatonin (MEL), a chronobiological synchronizing hormone primarily secreted by the pineal gland, with higher abundance during the dark cycle, has been increasingly studied beyond its role in regulating the circadian cycle. The exogenous administration of this hormone associated with athletic performance has been linked to different effects, given its role in circadian regulation in various tissues, potentially resulting in ergogenic effects. However, there is no consensus in the literature regarding the impact of acute supplementation on performance in aerobic exercise and post-exercise recovery. Objectives: To investigate the impact of acute melatonina administration on athletic performance during aerobic exercise. Methods: In a crossover, randomized, placebo-controlled, double-blind study, 13 healthy and physically active subjects underwent two experimental visits in the afternoon, where they underwent a session of aerobic exercise on a treadmill, consisting of 20 minutes at 60% of Vpeak, followed by a 1.5 km time-trial test with acute supplementation of MEL (10mg) or placebo. During the time trial test, data on time, speed, heart rate, and rating of perceived exertion were collected every 300 meters. Blood samples (Creatine Kinase and Lactate Dehydrogenase) were collected at baseline (BAS), immediately after moderate exercise (MOD), immediately after the time-trial (TT), 30 minutes (REC), and 24 hours (24H) after the exercise session. The BRUMS was completed during BAS, TT, and REC intervals. Body temperature (BT), diastolic (DBP), and systolic (SBP) blood pressure were collected at BAS, POST SUP (25 minutes post- MEL supplementation), MOD, TT, and REC. The QTR scale (recovery quality) was assessed only (24 H). Results: Melatonin did not impact performance in the time-trial test (p>0.05) or other physiological parameters assessed during the test. However, DBP after the time-trial test was lower in the Melatonin condition (p=0.03) (TT*MEL vs. TT*PLA). Conclusion: Acute MEL administration of 10 mg melatonin, offered 30 minutes before aerobic exercise, appears not to impact athletic performance but positively controls DBP values after aerobic exercise.
Introduction: Melatonin (MEL), a chronobiological synchronizing hormone primarily secreted by the pineal gland, with higher abundance during the dark cycle, has been increasingly studied beyond its role in regulating the circadian cycle. The exogenous administration of this hormone associated with athletic performance has been linked to different effects, given its role in circadian regulation in various tissues, potentially resulting in ergogenic effects. However, there is no consensus in the literature regarding the impact of acute supplementation on performance in aerobic exercise and post-exercise recovery. Objectives: To investigate the impact of acute melatonina administration on athletic performance during aerobic exercise. Methods: In a crossover, randomized, placebo-controlled, double-blind study, 13 healthy and physically active subjects underwent two experimental visits in the afternoon, where they underwent a session of aerobic exercise on a treadmill, consisting of 20 minutes at 60% of Vpeak, followed by a 1.5 km time-trial test with acute supplementation of MEL (10mg) or placebo. During the time trial test, data on time, speed, heart rate, and rating of perceived exertion were collected every 300 meters. Blood samples (Creatine Kinase and Lactate Dehydrogenase) were collected at baseline (BAS), immediately after moderate exercise (MOD), immediately after the time-trial (TT), 30 minutes (REC), and 24 hours (24H) after the exercise session. The BRUMS was completed during BAS, TT, and REC intervals. Body temperature (BT), diastolic (DBP), and systolic (SBP) blood pressure were collected at BAS, POST SUP (25 minutes post- MEL supplementation), MOD, TT, and REC. The QTR scale (recovery quality) was assessed only (24 H). Results: Melatonin did not impact performance in the time-trial test (p>0.05) or other physiological parameters assessed during the test. However, DBP after the time-trial test was lower in the Melatonin condition (p=0.03) (TT*MEL vs. TT*PLA). Conclusion: Acute MEL administration of 10 mg melatonin, offered 30 minutes before aerobic exercise, appears not to impact athletic performance but positively controls DBP values after aerobic exercise.
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Citação
SANTOS, Iago Diniz. Efeito da administração aguda de melatonina no desempenho em exercício fisico aeróbio: estudo randomizado, cruzado, duplo-cego e placebo controlado. 2024. 157 f. Tese (Doutorado em Psicobiologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2024.