Estrogen therapy reduces nocturnal periodic limb movements
Data
2007-11-20
Autores
Baracat, Edmund Chada 
Soares, Jose Maria
Haidar, Mauro Abi
Mello, Marco Tulio de
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It is believed that periodic lirnb movement (PLM) and more specifically, restless leg syndrome (RLS), are a common cause of insomnia. and one study in the literature examined PLM when associated to the use of estrogens. Polo-Kantola et al. [Polo-Kantola P, Rauhala E, Erkkola R, Irjala K, Polo O. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. Obstet Gynecol 2001;97(4):548-54] observed that estrogen therapy improved subjective sleep quality regardless of periodic limb movements or related arousals. Herein is a case of a symptomatic postmenopausal patient with high PLM index who complained of insomnia and leg pain. Given that the patient had hot flashes and a high Kupperman Menopausal Index (which evaluates climacteric symptoms), we decided to administer transdermal ESTRADOT 25 mu g (Novartis, Brazil) twice-a-week. Our patient experienced a significant decrease in PLM as well as a great increase in REM and a slight increase in slow wave sleep (stages 3 and 4), as shown in the polysomnography. the patient reported an overall improvement in her condition. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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Maturitas. Clare: Elsevier B.V., v. 58, n. 3, p. 319-322, 2007.