Estrogen therapy reduces nocturnal periodic limb movements

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dc.contributor.authorHachul, Helena
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.authorSoares, Jose Maria [UNIFESP]
dc.contributor.authorHaidar, Mauro Abi [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:13Z
dc.date.available2016-01-24T13:49:13Z
dc.date.issued2007-11-20
dc.description.abstractIt is believed that periodic lirnb movement (PLM) and more specifically, restless leg syndrome (RLS), are a common cause of insomnia. and one study in the literature examined PLM when associated to the use of estrogens. Polo-Kantola et al. [Polo-Kantola P, Rauhala E, Erkkola R, Irjala K, Polo O. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. Obstet Gynecol 2001;97(4):548-54] observed that estrogen therapy improved subjective sleep quality regardless of periodic limb movements or related arousals. Herein is a case of a symptomatic postmenopausal patient with high PLM index who complained of insomnia and leg pain. Given that the patient had hot flashes and a high Kupperman Menopausal Index (which evaluates climacteric symptoms), we decided to administer transdermal ESTRADOT 25 mu g (Novartis, Brazil) twice-a-week. Our patient experienced a significant decrease in PLM as well as a great increase in REM and a slight increase in slow wave sleep (stages 3 and 4), as shown in the polysomnography. the patient reported an overall improvement in her condition. (C) 2007 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med & Sleep Biol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med & Sleep Biol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent319-322
dc.identifierhttp://dx.doi.org/10.1016/j.maturitas.2007.08.009
dc.identifier.citationMaturitas. Clare: Elsevier B.V., v. 58, n. 3, p. 319-322, 2007.
dc.identifier.doi10.1016/j.maturitas.2007.08.009
dc.identifier.issn0378-5122
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30152
dc.identifier.wosWOS:000251541200013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMaturitas
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectperiodic leg movementsen
dc.subjectmenopauseen
dc.subjectestrogen therapyen
dc.subjectsleepen
dc.subjectsleep disturbancesen
dc.titleEstrogen therapy reduces nocturnal periodic limb movementsen
dc.typeinfo:eu-repo/semantics/article
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