Potencial hidrogeniônico de soluções de omeprazol após a trituração e dissolução com água e bicarbonato de sódio
Data
2022
Autores
Almeida, Maria Angélica Randoli de 
Orientadores
Peterlini, Maria Angélica Sorgini
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Potencial hidrogeniônico de soluções de omeprazol após a trituração e dissolução com água ou bicarbonato de sódio
Objetivos: Verificar o potencial hidrogeniônico (pH) de soluções de omeprazol preparadas a partir da abertura de cápsulas com a trituração dos microgrânulos gastrorresistentes e dissolução com dois tipos de água e bicarbonato de sódio 8,4%; e identificar a variação do pH das soluções segundo tempo após o preparo. Método: Estudo do tipo experimental realizado no Laboratório de Experimentos de Enfermagem (LEEnf), da Escola Paulista de Enfermagem – Universidade Federal de São Paulo. Prepararam-se soluções de omeprazol (20 mg), abrindo-se três cápsulas, dispensando-se os microgrânulos em almofariz de porcelana para trituração. A seguir, procedeu-se à pesagem em balança analítica (Shimadzu®, modelo AUY220, Kyoto, Japão), distribuído o conteúdo resultante da trituração em três béqueres de forma igualitária e acrescidos de 10 mL de solvente (água destilada, água deionizada ou solução de bicabornato de sódio a 8,4%), a fim de obter soluções com concentração final aproximadamente de 2 mg/mL de omeprazol. Houve o controle do pH dos solventes em medidor de pH digital de bancada (Kasvi® K39-2014B, Curitiba, Brasil), antes do início do experimento. Este procedimento foi realizado em triplicatas, resultando em nove soluções a serem analisadas. Verificaram-se os pHs das soluções imediatamente (T0), em 30 (T30) e 60 (T60) minutos após o preparo; as verificações aconteceram em duplicata, resultando na amostra de 57 análises. Adicionalmente, foi observado o aspecto físico das soluções no decorrer do tempo estudado. Os resultados foram analisados segundo a média (± desvio padrão), bem como os testes Anova e de Tukey, estabelecendo significância de 5%. Resultados: Os valores de pH dos solventes foram de 7,24 da água destilada; 7,34 da deionizada e 8,50 do bicarbonato de sódio 8,4%. As médias dos pHs iniciais e finais (T0 e T60) foram: 6,75 (±0,01) e 6,57 (±0,04) com a água destilada; 6,70 (±0,06) e 6,47 (±0,01) com a deionizada; e 8,43 (±0,01) e 8,53 (±0,01) com o bicarbonato de sódio 8,4%. Houve diferença estatisticamente significante entre os valores de pH das soluções preparadas com os diferentes solventes (p<0,001) e no decorrer do tempo após o preparo (p<0,001). Foi observada alteração de coloração das soluções quando se utilizaram as águas, passando de branca para rósea, enquanto com bicarbonato de sódio 8,4% manteve-se a coloração branca, durante o período de avaliação. Conclusão: Independentemente do solvente utilizado, os valores de pH alteram no decorrer do tempo após o preparo. Apesar de diferença estatística, as soluções com bicarbonato de sódio 8,4% resultaram em pH próximo ao do solvente e manteve-se o aspecto físico até 60 minutos.
Descritores: enfermagem, enfermagem pediátrica, dissolução, omeprazol, soluções, concentração de íons de hidrogênio, bicarbonato de sódio.
Hydrogen potential of omeprazole solutions after grinding and dissolving with water or sodium bicarbonate. Objectives: To verify the hydrogen ion potential (pH) of omeprazole solutions prepared by opening capsules with grinding of gastroresistant microgranules and dissolution with two types of water and 8.4% sodium bicarbonate; and to identify the pH variation of the solutions according to the time after preparation. Method: An experimental study carried out at the Laboratory of Nursing Experiments (LEEnf), at Escola Paulista de Enfermagem – Universidade Federal de São Paulo. Omeprazole solutions (20 mg) were prepared by opening three capsules and dispensing the microgranules in a porcelain mortar for grinding. Next, weighing was carried out on an analytical balance (Shimadzu®, model AUY220, Kyoto, Japan), the content resulting from grinding was distributed equally in three beakers and added with 10 mL of solvent (distilled water, deionized water or solution of 8.4% sodium bicarbonate) in order to obtain solutions with a final concentration of approximately 2 mg/mL of omeprazole. The pH of the solvents was controlled using a digital benchtop pH meter (Kasvi® K39-2014B, Curitiba, Brazil) before the beginning of the experiment. This procedure was performed in triplicates, resulting in nine solutions to be analyzed. The pH of the solutions was checked immediately (T0), 30 (T30) and 60 (T60) minutes after preparation; the checks took place in duplicate, resulting in a sample of 57 analyses. Additionally, the physical aspect of the solutions over the time studied was observed. The results were analyzed according to the mean (± standard deviation), as well as the Anova and Tukey tests, establishing a significance of 5%. Results: The pH values of the solvents were 7.24 of distilled water; 7.34 of deionized and 8.50 of 8.4% sodium bicarbonate. The initial and final pH averages (T0 and T60) were: 6.75 (±0.01) and 6.57 (±0.04) with distilled water; 6.70 (±0.06) and 6.47 (±0.01) with deionized; and 8.43 (±0.01) and 8.53 (±0.01) with 8.4% sodium bicarbonate. There was a statistically significant difference between the pH values of the solutions prepared with different solvents (p<0.001) and over time after preparation (p<0.001). A change in color of the solutions was observed when water was used, changing from white to pink, while with sodium bicarbonate 8.4% the white color was maintained during the evaluation period. Conclusion: Regardless of the solvent used, pH values change over time after preparation. Despite the statistical difference, the solutions with 8.4% sodium bicarbonate resulted in a pH close to that of the solvent and the physical appearance was maintained for up to 60 minutes. Descriptors: nursing, pediatric nursing, dissolution, omeprazole, solutions, Hydrogen Ion Concentration, sodium bicarbonate.
Hydrogen potential of omeprazole solutions after grinding and dissolving with water or sodium bicarbonate. Objectives: To verify the hydrogen ion potential (pH) of omeprazole solutions prepared by opening capsules with grinding of gastroresistant microgranules and dissolution with two types of water and 8.4% sodium bicarbonate; and to identify the pH variation of the solutions according to the time after preparation. Method: An experimental study carried out at the Laboratory of Nursing Experiments (LEEnf), at Escola Paulista de Enfermagem – Universidade Federal de São Paulo. Omeprazole solutions (20 mg) were prepared by opening three capsules and dispensing the microgranules in a porcelain mortar for grinding. Next, weighing was carried out on an analytical balance (Shimadzu®, model AUY220, Kyoto, Japan), the content resulting from grinding was distributed equally in three beakers and added with 10 mL of solvent (distilled water, deionized water or solution of 8.4% sodium bicarbonate) in order to obtain solutions with a final concentration of approximately 2 mg/mL of omeprazole. The pH of the solvents was controlled using a digital benchtop pH meter (Kasvi® K39-2014B, Curitiba, Brazil) before the beginning of the experiment. This procedure was performed in triplicates, resulting in nine solutions to be analyzed. The pH of the solutions was checked immediately (T0), 30 (T30) and 60 (T60) minutes after preparation; the checks took place in duplicate, resulting in a sample of 57 analyses. Additionally, the physical aspect of the solutions over the time studied was observed. The results were analyzed according to the mean (± standard deviation), as well as the Anova and Tukey tests, establishing a significance of 5%. Results: The pH values of the solvents were 7.24 of distilled water; 7.34 of deionized and 8.50 of 8.4% sodium bicarbonate. The initial and final pH averages (T0 and T60) were: 6.75 (±0.01) and 6.57 (±0.04) with distilled water; 6.70 (±0.06) and 6.47 (±0.01) with deionized; and 8.43 (±0.01) and 8.53 (±0.01) with 8.4% sodium bicarbonate. There was a statistically significant difference between the pH values of the solutions prepared with different solvents (p<0.001) and over time after preparation (p<0.001). A change in color of the solutions was observed when water was used, changing from white to pink, while with sodium bicarbonate 8.4% the white color was maintained during the evaluation period. Conclusion: Regardless of the solvent used, pH values change over time after preparation. Despite the statistical difference, the solutions with 8.4% sodium bicarbonate resulted in a pH close to that of the solvent and the physical appearance was maintained for up to 60 minutes. Descriptors: nursing, pediatric nursing, dissolution, omeprazole, solutions, Hydrogen Ion Concentration, sodium bicarbonate.
Descrição
Citação
ALMEIDA, M A R. Potencial hidrogeniônico de soluções de omeprazol após a trituração e dissolução com água e bicarbonato de sódio. São Paulo, 2022. 52 f. Dissertação (Mestrado em Enfermagem) – Escola Paulista de Enfermagem (EPE), Universidade Federal de São Paulo (UNIFESP). São Paulo 2022.