Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?

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dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.authorChavante, Suely Ferreira [UNIFESP]
dc.contributor.authorSantos, Elizeu Antunes dos
dc.contributor.authorOliveira, Fernanda Wanderley
dc.contributor.authorPaiva, José Fernandes de [UNIFESP]
dc.contributor.authorJerônimo, Selma Maria Bezerra
dc.contributor.authorMedeiros, Guilherme Fulgencio de [UNIFESP]
dc.contributor.authorAbreu, Luiz Roberto Diz de [UNIFESP]
dc.contributor.authorLeite, Edda Lisboa
dc.contributor.authorSousa-Filho, João Felipe de
dc.contributor.authorCastro, Rodrigo de Aquino [UNIFESP]
dc.contributor.authorToma, Leny [UNIFESP]
dc.contributor.authorTersariol, Ivarne Luis dos Santos [UNIFESP]
dc.contributor.authorPorcionatto, Marimélia Aparecida [UNIFESP]
dc.contributor.authorDietrich, Carl Peter [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionA02
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte
dc.contributor.institutionUniversidade de Mogi das Cruzes
dc.date.accessioned2015-06-14T13:24:52Z
dc.date.available2015-06-14T13:24:52Z
dc.date.issued1999-05-01
dc.description.abstractThe distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationA02
dc.description.affiliationUniversidade Federal do Rio Grande do Norte
dc.description.affiliationUniversidade de Mogi das Cruzes
dc.description.affiliationUnifespUNIFESP, EPM
dc.description.sourceSciELO
dc.format.extent529-538
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1999000500005
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 529-538, 1999.
dc.identifier.doi10.1590/S0100-879X1999000500005
dc.identifier.fileS0100-879X1999000500005.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1999000500005
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/775
dc.identifier.wosWOS:000080489600005
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectheparin - occurrence and functionen
dc.subjectheparan sulfate - occurrence and functionen
dc.subjectheparin - invertebratesen
dc.subjectheparan sulfate - invertebratesen
dc.subjectheparin and heparan sulfate - structureen
dc.titleHeparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates?en
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