CHARACTERIZATION OF GLYCOPROTEIN GP43, THE MAJOR LAMININ-BINDING PROTEIN OF PARACOCCIDIOIDES-BRASILIENSIS
Data
1994-09-01
Autores
Lopes, Jose Daniel 
Campos, Maria Cecilia Reis de Moura
Gesztesi, Jean-Luc
Mostrar mais
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
We have demonstrated that laminin mediates the adhesion of P. brasiliensis to monolayers of epithelial cells through specific binding to the surface glycoprotein gp43. This binding seems to be related to the fungal pathogenesis. We now report the confirmation of these findings by scanning electron microscopy and show that some isolates that do not secrete gp43 do express the protein as seen by studying whole cell extracts. These results confirm the ability of these strains to produce paracoccidioidomycosis but should not be used for serological purposes since the absence of gp43 in exoantigens may lead to false negative results.
Descrição
Citação
Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 9, p. 2309-2313, 1994.