CHARACTERIZATION OF GLYCOPROTEIN GP43, THE MAJOR LAMININ-BINDING PROTEIN OF PARACOCCIDIOIDES-BRASILIENSIS

CHARACTERIZATION OF GLYCOPROTEIN GP43, THE MAJOR LAMININ-BINDING PROTEIN OF PARACOCCIDIOIDES-BRASILIENSIS

Author Lopes, Jose Daniel Autor UNIFESP Google Scholar
Campos, Maria Cecilia Reis de Moura Autor UNIFESP Google Scholar
Vicentini, A. P. Google Scholar
Gesztesi, Jean-Luc Autor UNIFESP Google Scholar
Desouza, W. Google Scholar
Camargo, Zoilo Pires de Autor UNIFESP Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Abstract We have demonstrated that laminin mediates the adhesion of P. brasiliensis to monolayers of epithelial cells through specific binding to the surface glycoprotein gp43. This binding seems to be related to the fungal pathogenesis. We now report the confirmation of these findings by scanning electron microscopy and show that some isolates that do not secrete gp43 do express the protein as seen by studying whole cell extracts. These results confirm the ability of these strains to produce paracoccidioidomycosis but should not be used for serological purposes since the absence of gp43 in exoantigens may lead to false negative results.
Keywords P-BRASILIENSIS
GP43
MONOCLONAL ANTIBODIES
LAMININ
PROTEIN ISOFORMS
Language English
Date 1994-09-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 9, p. 2309-2313, 1994.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 2309-2313
Access rights Closed access
Type Article
Web of Science ID WOS:A1994PG03900025
URI http://repositorio.unifesp.br/11600/43079

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