A influência da radiação IV no microbioma da pele
Data
2023-06-26
Autores
Requena, Bruna Sousa 
Orientadores
Lopes, Patricia Santos
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
A pele humana é um vasto órgão que abriga uma ampla variedade de microrganismos, a maioria dos quais é inofensiva ou até benéfica ao hospedeiro. A colonização de microrganismos na pele é influenciada por vários fatores, como a localização no corpo, os fatores do hospedeiro e os fatores ambientais. Métodos moleculares recentes revelaram que o microbioma da pele é altamente diverso e variável. Uma compreensão melhor do microbioma da pele é imprescindível para entender distúrbios da pele e desenvolver novas abordagens para seu tratamento, incluindo terapias pró e antimicrobianas. O sistema imunológico da pele pode afetar a microbiota e, inversamente, a microbiota pode educar o sistema imunológico. Danos na pele causados pela radiação solar estão comumente relacionados à exposição à radiação UV. A terapia UV tem sido observada afetando o microbioma da pele, perturbando a função da barreira da pele e levando ao desenvolvimento de células T de memória residentes na pele específicas para microrganismos. Isso pode afetar o equilíbrio natural entre o microbioma da pele e as células imunológicas, levando a inflamações crônicas e doenças de pele. No entanto, a pele também está exposta à radiação IV. A radiação IV tem o potencial de criar radicais livres na pele, que podem desencadear vários caminhos de sinalização e causar efeitos terapêuticos ou prejudiciais, dependendo da quantidade de radiação recebida. Portanto, entender o impacto da radiação IV no microbioma da pele é importante para desenvolver estratégias eficazes para tratar e prevenir distúrbios da pele.
Human skin is a vast organ that harbors a wide variety of microorganisms, most of which are harmless or even beneficial to the host. The colonization of microorganisms on the skin is influenced by several factors, such as location on the body, host factors and environmental factors. Recent molecular methods have revealed that the skin microbiome is highly diverse and variable. A better understanding of the skin microbiome is critical to understanding skin disorders and developing new approaches to treating them, including pro- and antimicrobial therapies. The skin's immune system can affect the microbiota, and conversely, the microbiota can educate the immune system. Skin damage caused by solar radiation is commonly related to exposure to UV radiation. UV therapy has been observed to affect the skin's microbiome, disrupting the skin's barrier function and leading to the development of skin-resident memory T cells specific for microorganisms. This can affect the natural balance between the skin's microbiome and immune cells, leading to chronic inflammation and skin disease. However, the skin is also exposed to IR radiation. IR radiation has the potential to create free radicals in the skin, which can trigger various signaling pathways and cause therapeutic or harmful effects, depending on the amount of radiation received. Therefore, understanding the impact of IR radiation on the skin microbiome is important for developing effective strategies to treat and prevent skin disorders.
Human skin is a vast organ that harbors a wide variety of microorganisms, most of which are harmless or even beneficial to the host. The colonization of microorganisms on the skin is influenced by several factors, such as location on the body, host factors and environmental factors. Recent molecular methods have revealed that the skin microbiome is highly diverse and variable. A better understanding of the skin microbiome is critical to understanding skin disorders and developing new approaches to treating them, including pro- and antimicrobial therapies. The skin's immune system can affect the microbiota, and conversely, the microbiota can educate the immune system. Skin damage caused by solar radiation is commonly related to exposure to UV radiation. UV therapy has been observed to affect the skin's microbiome, disrupting the skin's barrier function and leading to the development of skin-resident memory T cells specific for microorganisms. This can affect the natural balance between the skin's microbiome and immune cells, leading to chronic inflammation and skin disease. However, the skin is also exposed to IR radiation. IR radiation has the potential to create free radicals in the skin, which can trigger various signaling pathways and cause therapeutic or harmful effects, depending on the amount of radiation received. Therefore, understanding the impact of IR radiation on the skin microbiome is important for developing effective strategies to treat and prevent skin disorders.