A prolactin-secreting tumor in a patient with Klinefelter's syndrome: A case report

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dc.contributor.authorPinto, Ana Claudia AR [UNIFESP]
dc.contributor.authorCzepielewski, M. A.
dc.contributor.authorGross, J. L.
dc.contributor.authorMussio, W. [UNIFESP]
dc.contributor.authorLengyel, AMJ [UNIFESP]
dc.contributor.institutionUNIV FED RIO GRANDE SUL
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:58:44Z
dc.date.available2018-06-15T17:58:44Z
dc.date.issued1996-04-01
dc.description.abstractWe report the case of a patient with Klinefelter's syndrome who developed a prolactin (PRL)-secreting tumor. The patient developed headaches, visual alterations and also symptoms of hypogonadism despite appropriate testosterone (T) replacement therapy, The diagnosis of hyperprolactinemia was then suspected. The laboratory findings confirmed the hypothesis, showing high levels of serum PRL. The patient was initially treated with oral bromocriptine, and afterwards with the injectable form. There was a marked decrease in PRL levels and in tumor size. Although some neoplasms, like breast carcinoma and germ cell tumors, are known to occur more frequently in patients with Klinefelter's syndrome, an association with PRL-secreting tumor has not been reported yet. In conclusion, symptoms of hypogonadism in patients with Klinefelter's syndrome receiving appropriate T replacement therapy can suggest the presence of hyperprolactinemia.en
dc.description.affiliationUNIV FED RIO GRANDE SUL,DEPT MED,PORTO ALEGRE,RS,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent248-252
dc.identifierhttp://dx.doi.org/10.1007/BF03349876
dc.identifier.citationJournal Of Endocrinological Investigation. Milano: Editrice Kurtis S R L, v. 19, n. 4, p. 248-252, 1996.
dc.identifier.doi10.1007/BF03349876
dc.identifier.issn0391-4097
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44358
dc.identifier.wosWOS:A1996UU81000009
dc.language.isoeng
dc.publisherEditrice Kurtis S R L
dc.relation.ispartofJournal Of Endocrinological Investigation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectKlinefelter's syndromeen
dc.subjectprolactinomaen
dc.subjecthypogonadismen
dc.subjectestrogenen
dc.subjecttestosteroneen
dc.subjecttumor formationen
dc.titleA prolactin-secreting tumor in a patient with Klinefelter's syndrome: A case reporten
dc.typeinfo:eu-repo/semantics/article
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