Funções musicais, memória musical-emocional e volume amigdaliano na doença de Alzheimer
Arquivos
Data
2010
Autores
Correia, Cléo Monteiro França 
Orientadores
Bertolucci, Paulo Henrique Ferreira
Tipo
Tese de doutorado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivos: Avaliar o desempenho de pacientes com doenca de Alzheimer (DA) e controles nos testes de avaliacao das funcoes musicais. Correlacionar os achados da avaliacao neuropsicologica com os das funcoes musicais. Comparar o desempenho dos pacientes com DA e o dos controles no teste de memoria sonora nao-verbal e correlacionar os achados da avaliacao da memoria musical-emocional com a volumetria dos corpos amigdaloides e hipocampos em pacientes com doenca de Alzheimer e controles. Metodos: Foram examinados pacientes com provavel DA em fase inicial e controles atraves dos Testes para Avaliacao do Ritmo Espontaneo, das Funcoes Musicais (envolvendo os aspectos perceptivos, gnosicos, gnosico-praxicos e de transposicao) e da Memoria musical-emocional, parte da Bateria Neuropsicologica Breve (NEUROPSI), teste de memoria logica e o Mini-Exame do Estado Mental (MEEM). Realizou-se a volumetria das estruturas temporais mediais atraves da ressonancia magnetica. Resultados: Foram avaliados 15 pacientes com DA e 16 controles. Os grupos eram semelhantes nas variaveis demograficas. O grupo de pacientes com DA mostrou bom desempenho na maioria dos testes perceptivos, com excecao do relacionado a duracao sonora e parte dos testes gnosico-praxicos, mas apresentou comprometimento nos Testes de Memoria para Sons Nao-verbais, de Transposicao Audiovisual e de Memoria Auditiva Nao-verbal. O ritmo espontaneo foi mais rapido que nos controles. Houve associacao significante entre a cognicao geral, mensurada pelo MEEM, e o Teste de Memoria Auditiva para Sons Nao-verbais e entre os Testes de Memoria musical-emocional e o de Memoria Logica. Quanto maior a volumetria do corpo amigdaloide e hipocampo, maior o escore na rememoracao autobiografica, criacao de imagens mentais e contextualizacao das musicas. Conclusoes: Os resultados sugerem que precocemente na DA pode haver comprometimento da percepcao do tempo e do reconhecimento de sons do meio-ambiente. Por outro lado, a memoria explicita mostra-se prejudicada na fase inicial da doenca, enquanto que a memoria musical mostra-se preservada principalmente para musicas familiares. Esses dados permitem supor que a estimulacao da memoria musical pode se tornar um recurso possivel para a reabilitacao na DA
Purpose: To study the performance of Alzheimer’s subjects and elderly controls in musical abilities tests. To correlate neuropsychology tests findings with those of musical abilities. To compare the performance of control group and Alzheimer’s patients in non verbal sound memory test and to correlate findings of emotional musical memory evaluation with the amygdala and hippocampal volumes in subjects with Alzheimer’s disease (AD) and control group. Methods: Alzheimer´s disease subjects and controls carried out music ability tests including spontaneous rhythm, perception of elemental music functions (tone color, duration, height and intensity), complex structures tests recognition and reproduction of musical parameters, organization and reproduction of rhythmic corporal movements, non-verbal sound memory test, emotional musical memory test, a portion of the Brief Neuropsychological Test, a logical memory test and the Mini-Mental State Examination (MMSE). We performed magnetic resonance imaging-based volumetric measurements of the medial temporal lobe structures. Results: We studied 15 early Alzheimer´s subjects and 16 controls. The groups were similar in demographics. Alzheimer´s subjects showed a good performance in most tests of perception, except for sound duration, but showed impairment on tests of memory for non-verbal sounds, and in audiovisual translating and auditory verbal memory.. The spontaneous rhythm was faster than in controls. There was a significant association between overall cognition as measured by MMSE and the test of non-verbal sounds and between emotional music memory and logical memory tests. The higher the volumetry of the hippocampus and amygdaloid body, higher the score in autobiographical recollections, creating mental images and background music. Conclusions: The results suggest that early in AD there may be impairment of time perception and recognition of environmental sounds. Moreover, explicit memory appears to be impaired in early stage disease, while the musical memory remains preserved mainly for familiar songs. These data support the hypothesis that the stimulation of musical memory can become a possible resource for rehabilitation in AD.
Purpose: To study the performance of Alzheimer’s subjects and elderly controls in musical abilities tests. To correlate neuropsychology tests findings with those of musical abilities. To compare the performance of control group and Alzheimer’s patients in non verbal sound memory test and to correlate findings of emotional musical memory evaluation with the amygdala and hippocampal volumes in subjects with Alzheimer’s disease (AD) and control group. Methods: Alzheimer´s disease subjects and controls carried out music ability tests including spontaneous rhythm, perception of elemental music functions (tone color, duration, height and intensity), complex structures tests recognition and reproduction of musical parameters, organization and reproduction of rhythmic corporal movements, non-verbal sound memory test, emotional musical memory test, a portion of the Brief Neuropsychological Test, a logical memory test and the Mini-Mental State Examination (MMSE). We performed magnetic resonance imaging-based volumetric measurements of the medial temporal lobe structures. Results: We studied 15 early Alzheimer´s subjects and 16 controls. The groups were similar in demographics. Alzheimer´s subjects showed a good performance in most tests of perception, except for sound duration, but showed impairment on tests of memory for non-verbal sounds, and in audiovisual translating and auditory verbal memory.. The spontaneous rhythm was faster than in controls. There was a significant association between overall cognition as measured by MMSE and the test of non-verbal sounds and between emotional music memory and logical memory tests. The higher the volumetry of the hippocampus and amygdaloid body, higher the score in autobiographical recollections, creating mental images and background music. Conclusions: The results suggest that early in AD there may be impairment of time perception and recognition of environmental sounds. Moreover, explicit memory appears to be impaired in early stage disease, while the musical memory remains preserved mainly for familiar songs. These data support the hypothesis that the stimulation of musical memory can become a possible resource for rehabilitation in AD.
Descrição
Citação
CORREIA, Cléo Monteiro França. Funções musicais, memória musical-emocional e volume amigdaliano na doença de Alzheimer. 2010. 179 f. Tese (Doutorado) – Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, 2010.