Conditioned immunosuppression of lipopolysaccharide-induced antibody response of orally immunized mice
Data
1997-06-01
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BALB/C mice previously conditioned in a paired regimen in which cycophosphamide was given in association with a novel taste in the drinking water (saccharin, SAC) subsequently received LPS (1mg/mouse) by oral gavage. Subgroups of mice were reexposed to SAC or water respectively, and anti-LPS antibody production measured 6 days later using an ELISA/ELISPOT assay. Our data show that the immune response to this T-independent antigen, administered orally, is amenable to conditioned immunosuppression in this model system. (C) 1997 Academic Press.
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Brain Behavior and Immunity. San Diego: Academic Press Inc Jnl-comp Subscriptions, v. 11, n. 2, p. 133-139, 1997.