A jornada de três meses com restrição calórica e suplementação com probióticos na busca pela melhora da composição corporal, da inflamação e do comportamento alimentar em homens adultos que vivem com obesidade
Data
2024-08-29
Autores
Lucin, Glaice Aparecida 
Orientadores
Santos, Ronaldo Vagner Thomatieli dos
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivo: A obesidade é caracterizada pela massa corporal desproporcional para a estatura, com acúmulo excessivo de tecido adiposo e acompanhada de um quadro de inflamação crônica e sistêmica de baixo grau. A suplementação com probióticos pode ser uma alternativa adicional para o seu tratamento. No entanto, dúvidas ainda persistem. Por isso, esse trabalho teve como objetivo avaliar se 12 semanas com intervenção de restrição calórica (RC) associada à suplementação com probióticos promoveria melhora na composição corporal, na inflamação sistêmica e no comportamento alimentar de homens que vivem com obesidade. Métodos: Estudo randomizado, duplo-cego, controlado por placebo, de dois grupos paralelos com homens adultos vivendo com obesidade grau I e II submetidos à intervenção de RC associada à suplementação probiótica por 12 semanas. 13 participantes foram alocados aleatoriamente para receber diariamente 2 de sachês de 1g cada da formulação de 1x109 UFC de cada espécie probiótica: Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus HN001, Lactobacillus paracasei Lpc-37 e Bifidobacterium lactis HN019 e 12 participantes para receber placebo, composto por maltodextrina. Todos os participantes receberam uma dieta com RC de 30% do gasto energético total (GET). A composição corporal, os níveis plasmáticos de leptina, grelina, insulina, adiponectina, GLP-1, PYY, TNF-α, IL-6, IL-10 e o comportamento alimentar foram avaliados antes e depois da intervenção. Resultados: Ambos os grupos apresentaram redução de massa corporal total (p<0,001), IMC (p<0,001), percentual de gordura corporal (p<0,001), massa gorda (p<0,001), área de gordura visceral (p<0,001), circunferência abdominal (p<0,001), circunferência de cintura (p<0,001), circunferência de quadril (p<0,001)) e circunferência de pescoço (p<0,001). Não houve diferença entre os grupos. No comportamento alimentar, foi observada diminuição significativa nas pontuações de descontrole alimentar e alimentação emocional no grupo que recebeu probióticos (p=0,018 e p=0,035 respectivamente). Não foram observadas diferenças significativas nas concentrações plasmáticas de hormônios e citocinas: grelina, insulina, GLP-1, leptina, adiponectina, TNF-α, IL-6, e IL-10. Conclusão: A intervenção de RC foi eficaz em promover melhora na composição corporal, porém a suplementação probiótica não apresentou efeitos adicionais. Ao contrário do comportamento alimentar, onde a suplementação probiótica ofereceu benefícios superiores aos alcançados apenas pela RC. A intervenção combinada de RC e suplementação probiótica reforça a hipótese de que o eixo intestino-cérebro pode influenciar o comportamento alimentar, um fator crucial no combate à obesidade.
Objective: Obesity is characterized by body mass disproportionate to height, with excessive accumulation of adipose tissue and accompanied by low-grade chronic and systemic inflammation. The supplementation with probiotics can be an additional alternative for its treatment. However, doubts persist. Therefore, this work aimed to evaluate whether 12 weeks of calorie restriction (CR) intervention associated with probiotic supplementation would improve body composition, systemic inflammation, and eating behavior in men living with obesity. Methods: Randomized, double-blind, placebo-controlled study of two parallel groups with adult men living with grade I and II obesity undergoing CR intervention associated with probiotic supplementation for 12 weeks. 13 participants were randomly allocated to receive daily 2 sachets of 1g each of the 1x109 UFC formulation of each probiotic species: Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus HN001, Lactobacillus paracasei Lpc-37 and Bifidobacterium lactis HN019 and 12 participants to receive placebo, consisting of maltodextrin. All participants received a diet with a CR of 30% of total energy expenditure (TEB). Body composition, plasma levels of leptin, ghrelin, insulin, adiponectin, GLP-1, PYY, TNF-α, IL-6, IL-10, and eating behavior were assessed before and after the intervention. Results: Both groups showed a reduction in total body mass (p<0.001), BMI (p<0.001), body fat percentage (p<0.001), fat mass (p<0.001), visceral fat area (p<0.001), abdominal circumference (p<0.001), waist circumference (p<0.001), hip circumference (p<0.001)) and neck circumference (p<0.001). There was no difference between the groups. In eating behavior, a significant decrease was observed in the lack of control overeating and emotional eating scores in the group that received probiotics (p=0.018 and p=0.035 respectively). No significant differences were observed in plasma concentrations of hormones and cytokines: ghrelin, insulin, GLP-1, leptin, adiponectin, TNF-α, IL-6, and IL-10. Conclusion: The CR intervention effectively promoted improvements in body composition, but probiotic supplementation did not have additional effects. Unlike eating behavior, where probiotic supplementation offered benefits superior to those achieved by CR alone. The combined intervention of CR and probiotic supplementation reinforces the hypothesis that the gut-brain axis can influence eating behavior, a crucial factor in combating obesity.
Objective: Obesity is characterized by body mass disproportionate to height, with excessive accumulation of adipose tissue and accompanied by low-grade chronic and systemic inflammation. The supplementation with probiotics can be an additional alternative for its treatment. However, doubts persist. Therefore, this work aimed to evaluate whether 12 weeks of calorie restriction (CR) intervention associated with probiotic supplementation would improve body composition, systemic inflammation, and eating behavior in men living with obesity. Methods: Randomized, double-blind, placebo-controlled study of two parallel groups with adult men living with grade I and II obesity undergoing CR intervention associated with probiotic supplementation for 12 weeks. 13 participants were randomly allocated to receive daily 2 sachets of 1g each of the 1x109 UFC formulation of each probiotic species: Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus HN001, Lactobacillus paracasei Lpc-37 and Bifidobacterium lactis HN019 and 12 participants to receive placebo, consisting of maltodextrin. All participants received a diet with a CR of 30% of total energy expenditure (TEB). Body composition, plasma levels of leptin, ghrelin, insulin, adiponectin, GLP-1, PYY, TNF-α, IL-6, IL-10, and eating behavior were assessed before and after the intervention. Results: Both groups showed a reduction in total body mass (p<0.001), BMI (p<0.001), body fat percentage (p<0.001), fat mass (p<0.001), visceral fat area (p<0.001), abdominal circumference (p<0.001), waist circumference (p<0.001), hip circumference (p<0.001)) and neck circumference (p<0.001). There was no difference between the groups. In eating behavior, a significant decrease was observed in the lack of control overeating and emotional eating scores in the group that received probiotics (p=0.018 and p=0.035 respectively). No significant differences were observed in plasma concentrations of hormones and cytokines: ghrelin, insulin, GLP-1, leptin, adiponectin, TNF-α, IL-6, and IL-10. Conclusion: The CR intervention effectively promoted improvements in body composition, but probiotic supplementation did not have additional effects. Unlike eating behavior, where probiotic supplementation offered benefits superior to those achieved by CR alone. The combined intervention of CR and probiotic supplementation reinforces the hypothesis that the gut-brain axis can influence eating behavior, a crucial factor in combating obesity.
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LUCIN, Glaice Aparecida. A jornada de três meses com restrição calórica e suplementação com probióticos na busca pela melhora da composição corporal, da inflamação e do comportamento alimentar em homens adultos que vivem com obesidade. 2024. 110 f. Dissertação (Mestrado em Psicobiologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP). São Paulo, 2024.