Efeitos da suplementação com polpa de juçara sobre o estado inflamatório causado pelo exercício exaustivo
Arquivos
Data
2017-12-13
Autores
Kubota, Melina Chiemi 
Orientadores
Estadella, Debora
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Durante e após a realização do exercício físico as concentrações de interleucinas (IL) 1β, 6, 10 e fator de necrose tumoral - alfa (TNF -α) nos músculos esqueléticos sofrem alterações, com grau possivelmente relacionado à intensidade do exercício realizado assim como a glicemia e o HDL no sangue e acarretam na alteração na concentração de glicogênio. A prática de exercícios exaustivos, sem treinamento prévio, pode ser deletéria a curto, médio ou longo prazo, pelo desequilíbrio causado nos níveis de citocinas, proteínas e enzimas que regulam os processos inflamatórios em níveis não fisiológicos. A polpa do fruto da palmeira juçara contém antocianina, composto fenólico conhecido por seu alto efeito anti-inflamatório e antioxidante. Desta forma o objetivo deste trabalho foi avaliar o efeito da suplementação da dieta com polpa da juçara antes da realização de uma única sessão de exercício exaustivo no que concerne a concentração no tecido muscular de glicogênio e das citocinas pró e anti-inflamatórias além das concentrações bioquímicas no soro. Utilizamos ratos machos Wistar com 10 semanas, divididos em: controle (C); controle Juçara (J); exercício (E); exercício com suplementação com polpa de juçara (EJ). Avaliamos as citocinas citadas acima nos múculos sóleo e EDL (extensor longo dos dedos), glicogênio as análises bioquímicas no soro. Observou no grupo E (E vs. C) aumento sericos de glicose, triacilglicerol e lactato e de citocinas IL-1β, IL-6, IL-10 e TNF-α no EDL e IL-1β e IL-10 no sóleo. No grupo EJ (EJ vs E) diminuição de triacilglicerol em niveis serico e das citocinas IL-1β, IL-6, IL-10 e TNF-α apenas no musculo sóleo. Podemos concluir que a realização de sessão única de exercício exaustivo sem treinamento prévio pode modular diversos parametros metabolicos e concentrações de citocinas pro e anti-inflamatorias nos musculos esqueléticos de ratos, e a suplementação da dieta com juçara demostrou potencial para reduzir esses alterações nos níveis de citocinas principalmente no musculo esqueletíco composto predominantemente fibras oxidativas (sóleo).
During and after physical exercise interleukins (IL) 1β, 6, 10 and tumor necrosis factor-alpha (TNFα), concentrations in the skeletal muscles changes, and this levels vary in degree possibly related to exercise intensity performed. The same he same can occur with glycemia and tissue levels of glycogen. The practice of exhaustive exercises, without previous training, can be deleterious in the short, medium or long term due to the imbalance caused in the levels of cytokines, proteins and enzymes that regulate inflammatory processes at non-physiological levels. The jussara palm fruit pulp contains anthocyanin, a phenolic compound known for its high anti-inflammatory and antioxidant effect. In this way, the objective of this work was to evaluate the effect of dietary supplementation with jussara pulp prior to a single exhaustive exercise session regarding the concentration of glycogen muscle tissue and pro and anti-inflammatory cytokines in addition to biochemical concentrations in the serum. Male Wistar rats (n=32), 10 weeks of age (weighing ~250g), divided into four groups with or without supplementation were used and who did or did not complete the exercise protocol, being: C (control); J (jussara pulp); E (exercise); EJ (exercise with jussara pulp). The inflammatory profile of the skeletal muscles was carried out by Elisa, and serum biochemical concentrations were measured with an enzymatic colorimetric method using commercial kits. The exhaustive exercise induced an increase in serum glucose in the group E (E vs. C) and in pro and anti-inflammatory cytokines in the skeletal muscles EDL and soleus. In the group EJ (EJ vs. E) decreased in cytokins only muscle soleus. Given the above, performing a single session of exhaustive exercise without prior training can modulate various metabolic parameters and pro and anti-inflammatory cytokines concentrations in the skeletal muscles of rats. The dietary supplementation with jussara has shown the potential to reduce such changes in levels of cytokines mainly in skeletal muscle composed predominantly of oxidative fibers (soleus).
During and after physical exercise interleukins (IL) 1β, 6, 10 and tumor necrosis factor-alpha (TNFα), concentrations in the skeletal muscles changes, and this levels vary in degree possibly related to exercise intensity performed. The same he same can occur with glycemia and tissue levels of glycogen. The practice of exhaustive exercises, without previous training, can be deleterious in the short, medium or long term due to the imbalance caused in the levels of cytokines, proteins and enzymes that regulate inflammatory processes at non-physiological levels. The jussara palm fruit pulp contains anthocyanin, a phenolic compound known for its high anti-inflammatory and antioxidant effect. In this way, the objective of this work was to evaluate the effect of dietary supplementation with jussara pulp prior to a single exhaustive exercise session regarding the concentration of glycogen muscle tissue and pro and anti-inflammatory cytokines in addition to biochemical concentrations in the serum. Male Wistar rats (n=32), 10 weeks of age (weighing ~250g), divided into four groups with or without supplementation were used and who did or did not complete the exercise protocol, being: C (control); J (jussara pulp); E (exercise); EJ (exercise with jussara pulp). The inflammatory profile of the skeletal muscles was carried out by Elisa, and serum biochemical concentrations were measured with an enzymatic colorimetric method using commercial kits. The exhaustive exercise induced an increase in serum glucose in the group E (E vs. C) and in pro and anti-inflammatory cytokines in the skeletal muscles EDL and soleus. In the group EJ (EJ vs. E) decreased in cytokins only muscle soleus. Given the above, performing a single session of exhaustive exercise without prior training can modulate various metabolic parameters and pro and anti-inflammatory cytokines concentrations in the skeletal muscles of rats. The dietary supplementation with jussara has shown the potential to reduce such changes in levels of cytokines mainly in skeletal muscle composed predominantly of oxidative fibers (soleus).
Descrição
Citação
KUBOTA, Melina Chiemi. Efeitos da suplementação com polpa de juçara sobre o estado inflamatório causado pelo exercício exaustivo. 2017. 33 f. Trabalho de conclusão de curso de graduação (Educação Física) - Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Santos, 2017.