The Paracoccidioides cell wall: past and present layers toward understanding interaction with the host

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dc.contributor.authorPuccia, Rosana [UNIFESP]
dc.contributor.authorVallejo, Milene Carmes [UNIFESP]
dc.contributor.authorMatsuo, Alisson Leonardo [UNIFESP]
dc.contributor.authorLongo, Larissa Valle Guilhen [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:54Z
dc.date.available2016-01-24T14:05:54Z
dc.date.issued2011-01-01
dc.description.abstractThe cell wall of pathogenic fungi plays import roles in the interaction with the host, so that its composition and structure may determine the course of infection. Here we present an overview of the current and past knowledge on the cell wall constituents of Paracoccidioides brasiliensis and P. lutzii. These are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis, a systemic granulomatous, and debilitating disease. Focus is given on cell wall carbohydrate and protein contents, their immune-stimulatory features, adhesion properties, drug target characteristics, and morphological phase specificity. We offer a journey toward the future understanding of the dynamic nature of the cell wall and of the changes that may occur when the fungus infects the human host.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.3389/fmicb.2011.00257
dc.identifier.citationFrontiers in Microbiology. Lausanne: Frontiers Research Foundation, v. 2, 7 p., 2011.
dc.identifier.doi10.3389/fmicb.2011.00257
dc.identifier.fileWOS000208863500265.pdf
dc.identifier.issn1664-302X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33234
dc.identifier.wosWOS:000208863500265
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcell wallen
dc.subjectParacoccidioides brasiliensisen
dc.subjectP. lutziien
dc.subjectpolysaccharidesen
dc.subjectadhesinsen
dc.subjectenzymesen
dc.subjecthost interactionen
dc.titleThe Paracoccidioides cell wall: past and present layers toward understanding interaction with the hosten
dc.typeinfo:eu-repo/semantics/article
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