The Paracoccidioides cell wall: past and present layers toward understanding interaction with the host
Data
2011-01-01
Autores
Puccia, Rosana 
Vallejo, Milene Carmes
Matsuo, Alisson Leonardo
Longo, Larissa Valle Guilhen
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
The cell wall of pathogenic fungi plays import roles in the interaction with the host, so that its composition and structure may determine the course of infection. Here we present an overview of the current and past knowledge on the cell wall constituents of Paracoccidioides brasiliensis and P. lutzii. These are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis, a systemic granulomatous, and debilitating disease. Focus is given on cell wall carbohydrate and protein contents, their immune-stimulatory features, adhesion properties, drug target characteristics, and morphological phase specificity. We offer a journey toward the future understanding of the dynamic nature of the cell wall and of the changes that may occur when the fungus infects the human host.
Descrição
Citação
Frontiers in Microbiology. Lausanne: Frontiers Research Foundation, v. 2, 7 p., 2011.